INT196141

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Context Info
Confidence 0.09
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.85
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cellular_component (Ostf1) biological_process (Ostf1) cytoplasm (Ostf1)
Anatomy Link Frequency
osteoclasts 2
Ostf1 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 1 96.44 Very High Very High Very High
cytokine 1 62.48 Quite High
Intractable pain 1 37.08 Quite Low
metalloproteinase 36 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 57 99.84 Very High Very High Very High
Cancer 146 97.96 Very High Very High Very High
Metastasis 74 97.28 Very High Very High Very High
Rheumatoid Arthritis 1 96.44 Very High Very High Very High
Osteoporosis 5 95.56 Very High Very High Very High
Hypercalcemia 7 95.08 Very High Very High Very High
Disease 1 92.64 High High
Osteolysis 3 83.88 Quite High
Necrosis 1 80.32 Quite High
Intractable Pain 1 37.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
3 integrin with bone ECM proteins may induce production of an osteoclast-stimulating factor, such as RANKL or colony stimulating factor 1, by tumor cells or by bone marrow cells.
Gene_expression (production) of osteoclast-stimulating factor in osteoclast associated with cancer
1) Confidence 0.09 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1557720 Disease Relevance 1.37 Pain Relevance 0.03
Earlier studies suggested that RANKL may be the long sought-after osteoclast activating factor, the critical factor expressed by breast cancer cells that functions as the stem cell factor for osteoclasts (Figure 1) [5].
Gene_expression (expressed) of osteoclast activating factor in osteoclasts associated with breast cancer
2) Confidence 0.04 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2374958 Disease Relevance 1.48 Pain Relevance 0.05

General Comments

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