INT196372

Context Info Confidence 0.19 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.91 Pain Relevance 0.22

mitochondrion (Alas1) biosynthetic process (Alas1) nucleus (Alas1) transferase activity, transferring acyl groups (Alas1) cytoplasm (Alas1)

Alas1 (Mus musculus)

Pain Link Frequency Relevance Heat peripheral neuropathy 4 73.04 abdominal pain 4 70.24

Disease Link Frequency Relevance Heat Porphyria 76 91.84 Nicotine Addiction 2 84.08 Syndrome 6 74.44 Peripheral Neuropathy 4 73.04 Abdominal Pain 4 70.24 Diabetic Nephropathy 2 68.84 Encephalopathy 2 66.76 Paranoid Disorders 2 65.32 Hallucination 4 64.32 Confusion 2 63.68

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This suppresses hepatic ALAS induction and the overproduction of ALA

Positive_regulation (induction) of ALAS

1) Confidence 0.19 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559910 Disease Relevance 0.66 Pain Relevance 0.11

Increased heme demand results in the induction of ALAS and increased synthesis of

Positive_regulation (induction) of ALAS

2) Confidence 0.13 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559910 Disease Relevance 1.25 Pain Relevance 0.11

General Comments

This test has worked.