INT196634

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Context Info
Confidence 0.03
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.49
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IFNG) extracellular region (IFNG) ATPase activity (DNAH8)
cytoskeleton (DNAH8) cilium (DNAH8) cytoplasm (DNAH8)
Anatomy Link Frequency
Caco-2 2
T84 1
IFNG (Homo sapiens)
DNAH8 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 63 96.44 Very High Very High Very High
Inflammation 102 83.76 Quite High
Crohn's disease 3 66.76 Quite High
Inflammatory mediators 60 52.44 Quite High
bradykinin 30 5.00 Very Low Very Low Very Low
sodium channel 27 5.00 Very Low Very Low Very Low
fibrosis 18 5.00 Very Low Very Low Very Low
adenocard 15 5.00 Very Low Very Low Very Low
agonist 15 5.00 Very Low Very Low Very Low
substance P 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diarrhoea 24 89.92 High High
INFLAMMATION 168 83.76 Quite High
Inflammatory Bowel Disease 12 70.16 Quite High
Disease 27 66.76 Quite High
Pyelonephritis 12 55.84 Quite High
Cryptosporidiosis 3 55.60 Quite High
Urinary Tract Infection 3 50.96 Quite High
Hyponatremia 9 46.16 Quite Low
Hyperkalemia 3 44.80 Quite Low
Colitis 9 34.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of the Na/K ATPase by IFN gamma was also observed in murine small intestine preparations and the intestinal epithelial Caco-2 cell line [58,59].
IFN gamma Negative_regulation (Inhibition) of ATPase in Caco-2
1) Confidence 0.03 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.62 Pain Relevance 0.21
Another study however noted that interferon gamma reduced Na/K ATPase activity without change in Na K ATPase expression in human intestinal Caco-2 cells [59].
interferon gamma Negative_regulation (reduced) of ATPase in Caco-2
2) Confidence 0.02 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.18 Pain Relevance 0.03
In the human colonic T84 cell line Na/K ATPase was inhibited by IFN gamma and NO and this was associated with an increase in cell volume and intracellular sodium concentration [57].
IFN gamma Negative_regulation (inhibited) of ATPase in T84
3) Confidence 0.02 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.69 Pain Relevance 0.23

General Comments

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