INT196647

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Context Info
Confidence 0.04
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.79
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IFNG) extracellular region (IFNG)
Anatomy Link Frequency
Caco-2 2
IFNG (Homo sapiens)
NA (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 42 96.44 Very High Very High Very High
Inflammation 68 83.76 Quite High
Crohn's disease 2 53.92 Quite High
Inflammatory mediators 40 39.60 Quite Low
bradykinin 20 5.00 Very Low Very Low Very Low
sodium channel 18 5.00 Very Low Very Low Very Low
fibrosis 12 5.00 Very Low Very Low Very Low
adenocard 10 5.00 Very Low Very Low Very Low
agonist 10 5.00 Very Low Very Low Very Low
substance P 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 112 83.76 Quite High
Diarrhoea 16 77.08 Quite High
Inflammatory Bowel Disease 8 70.16 Quite High
Cryptosporidiosis 2 55.60 Quite High
Pyelonephritis 8 55.12 Quite High
Disease 18 53.92 Quite High
Urinary Tract Infection 2 50.24 Quite High
Hyponatremia 6 45.44 Quite Low
Hyperkalemia 2 44.08 Quite Low
Colitis 6 34.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of the Na/K ATPase by IFN gamma was also observed in murine small intestine preparations and the intestinal epithelial Caco-2 cell line [58,59].
IFN gamma Negative_regulation (Inhibition) of Na in Caco-2
1) Confidence 0.04 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.62 Pain Relevance 0.21
Another study however noted that interferon gamma reduced Na/K ATPase activity without change in Na K ATPase expression in human intestinal Caco-2 cells [59].
interferon gamma Negative_regulation (reduced) of Na in Caco-2
2) Confidence 0.03 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.18 Pain Relevance 0.03

General Comments

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