INT196682

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Context Info
Confidence 0.34
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.96
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (CFTR) ATPase activity (CFTR) plasma membrane (CFTR)
enzyme binding (CFTR) protein complex (CFTR) transmembrane transport (CFTR)
Anatomy Link Frequency
T84 3
nasal 2
HT-29 1
CFTR (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 105 99.48 Very High Very High Very High
sodium channel 45 90.60 High High
depression 1 83.16 Quite High
backache 1 82.32 Quite High
Migraine 1 81.12 Quite High
headache 1 80.64 Quite High
Inflammation 170 72.20 Quite High
Inflammatory response 15 68.08 Quite High
Inflammatory mediators 100 44.64 Quite Low
bradykinin 50 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rhinitis 15 99.00 Very High Very High Very High
Sinusitis 10 96.12 Very High Very High Very High
Colitis 15 89.76 High High
Anxiety Disorder 1 83.60 Quite High
Depression 1 83.16 Quite High
Low Back Pain 1 82.32 Quite High
Headache 2 81.12 Quite High
Hypersensitivity 22 78.28 Quite High
Asthma 7 77.68 Quite High
INFLAMMATION 280 72.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It upregulated CFTR mRNA levels at a dose of 0.25 ng/ml and inhibited CFTR mRNA and protein expression at higher doses [1 ng/ml] in T 84 cells [86].
Negative_regulation (inhibited) of Gene_expression (expression) of CFTR mRNA
1) Confidence 0.34 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.14 Pain Relevance 0.08
Other cytokines which have been found to reduce CFTR mRNA and intracellular CFTR protein expression and integration in the apical membrane leading to a reduced epithelial secretory response in colonic epithelia [T84 and HT-29] were TGF beta 1 and interleukin-4 [83].
Negative_regulation (reduce) of Gene_expression (expression) of CFTR mRNA in T84 associated with cytokine
2) Confidence 0.25 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.07 Pain Relevance 0.05
In vitro studies have also found a reduction in CFTR gene and protein expression in chronically inflamed nasal polyps associated with a reduced cAMP-dependent short ciruit current in the Ussing chamber.
Negative_regulation (reduction) of Gene_expression (expression) of CFTR gene in nasal associated with rhinitis
3) Confidence 0.25 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.90 Pain Relevance 0.17
It upregulated CFTR mRNA levels at a dose of 0.25 ng/ml and inhibited CFTR mRNA and protein expression at higher doses [1 ng/ml] in T 84 cells [86].
Negative_regulation (inhibited) of Gene_expression (expression) of CFTR mRNA
4) Confidence 0.25 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.15 Pain Relevance 0.08
Difference in the number of missing answers between different modes of CHQ-CF administration
Negative_regulation (modes) of Gene_expression (administration) of CHQ-CF
5) Confidence 0.23 Published 2007 Journal Qual Life Res Section Body Doc Link PMC1832149 Disease Relevance 0.63 Pain Relevance 0.29
Other cytokines which have been found to reduce CFTR mRNA and intracellular CFTR protein expression and integration in the apical membrane leading to a reduced epithelial secretory response in colonic epithelia [T84 and HT-29] were TGF beta 1 and interleukin-4 [83].
Negative_regulation (reduce) of in HT-29 Gene_expression (expression) of CFTR mRNA in T84 associated with cytokine
6) Confidence 0.09 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.07 Pain Relevance 0.05

General Comments

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