INT196685

Context Info Confidence 0.37 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.60 Pain Relevance 0.03

transport (CFTR) ATPase activity (CFTR) plasma membrane (CFTR) enzyme binding (CFTR) protein complex (CFTR) transmembrane transport (CFTR)

Anatomy Link Frequency Calu-3 1 CFTR (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammatory response 6 52.48 Inflammation 68 50.00 sodium channel 18 44.52 fibrosis 12 19.68 cytokine 42 5.00 Inflammatory mediators 40 5.00 bradykinin 20 5.00 adenocard 10 5.00 agonist 10 5.00 substance P 6 5.00

Disease Link Frequency Relevance Heat Sepsis 8 96.40 Heart Rate Under Development 22 81.00 Meningitis 6 80.04 Systemic Inflammatory Response Syndrome 2 52.84 INFLAMMATION 112 50.00 Rhinitis 6 37.16 Sinusitis 4 30.00 Cystic Fibrosis 12 20.24 Hypersensitivity 8 5.56 Disease 18 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Inhibition of the Na/K ATPase in human pulmonary Calu-3 cells lead to a reduced transcription of CFTR [14].

Transcription (transcription) of CFTR in Calu-3

1) Confidence 0.37 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.60 Pain Relevance 0.03

This assay is used to measure the activity of the CFTR chloride channel in vitro.

Transcription (activity) of CFTR

2) Confidence 0.31 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.