INT196753

Context Info Confidence 0.37 First Reported 2006 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 0.52 Pain Relevance 0.70

cytosol (Ppp2ca) chromosome (Ppp2ca) plasma membrane (Ppp2ca) cytoskeleton (Ppp2ca) nucleus (Ppp2ca) cytoplasm (Ppp2ca)

Ppp2ca (Mus musculus)

Pain Link Frequency Relevance Heat Dopamine 248 93.04 antagonist 19 86.64 Eae 7 85.28 nMDA receptor 61 81.60 Glutamate 84 44.88 cytokine 2 9.96 Inflammation 9 9.60 Neurotransmitter 8 8.20 cocaine 31 5.00 Morphine 30 5.00

Disease Link Frequency Relevance Heat Death 13 100.00 Drug Induced Neurotoxicity 2 89.96 Disease 43 86.32 Toxicity 7 56.36 Hypoxia 6 28.00 Tauopathy 1 18.16 INFLAMMATION 6 9.60 Cognitive Disorder 10 5.00 Injury 10 5.00 Neurodegenerative Disease 9 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Removing the phosphorylation of PP2A by PKAc should decrease the modulation of phosphoThr75, and reduce the disinhibition of PKAc.

Negative_regulation (reduce) of Phosphorylation (phosphorylation) of PP2A

1) Confidence 0.37 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.21

Removing the phosphorylation of PP2A by PKAc should decrease the modulation of phosphoThr75, and reduce the disinhibition of PKAc.

Negative_regulation (decrease) of Phosphorylation (phosphorylation) of PP2A

2) Confidence 0.27 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.21

Memantine (10 µM) inhibited this abnormal phosphorylation of tau and cell death and prevented the I(2)(PP2A)-induced inhibition of PP2A activity with no effect on basal activity [47].

Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of PP2A associated with death

3) Confidence 0.03 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645549 Disease Relevance 0.52 Pain Relevance 0.27

General Comments

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