INT196816

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Context Info
Confidence 0.15
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Camk2a) cell cycle (Calm3) kinase activity (Camk2a)
cytoplasm (Camk2a)
Calm3 (Mus musculus)
Camk2a (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 31 71.52 Quite High
imagery 8 67.04 Quite High
Dopamine 120 50.00 Quite Low
long-term potentiation 12 5.00 Very Low Very Low Very Low
gABA 12 5.00 Very Low Very Low Very Low
depression 9 5.00 Very Low Very Low Very Low
Action potential 5 5.00 Very Low Very Low Very Low
projection neuron 4 5.00 Very Low Very Low Very Low
dopamine receptor 3 5.00 Very Low Very Low Very Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 9 5.00 Very Low Very Low Very Low
Adhesions 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The strength of the positive-feedback loop also depends on the affinity of CaMKII for Ca2+/CaM, as the autophosphorylation at Thr286/287 occurs after the association.
CaM Binding (affinity) of CaMKII
1) Confidence 0.15 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0
CaMKII was included in the model as a buffer for CaM; therefore only three reactions are included: reversible binding of CaM to CaMKII; a slow autophosphorylation into CaMKIIp, in which CaM is trapped; and dephosphorylation of CaMKIIp by PP1.
CaM Binding (buffer) of CaMKII
2) Confidence 0.03 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.14

General Comments

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