INT196834
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
LTP-inducing high-frequency stimulation has been reported to cause sustained DARPP-32 phosphorylation by PKA in a manner dependent on CaMKII in hippocampal slices (Atkins et al, 2005). | |||||||||||||||
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Thus, model simulations suggest that PKA activation, phosphorylation of DARPP-32 at Thr34, and subsequent PP1 inhibition, produced by conjunctive glutamate and D1 receptor stimulation, can produce LTP by increased phosphorylation of AMPA receptors. | |||||||||||||||
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General Comments
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