INT196834

Context Info Confidence 0.15 First Reported 2006 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0 Pain Relevance 0.87

cytoplasm (Prkaca, Ppp1r1b) nucleus (Prkaca, Ppp1r1b) mitochondrion (Prkaca) Golgi apparatus (Prkaca) intracellular (Ppp1r1b) protein complex (Prkaca)

Prkaca (Mus musculus) Ppp1r1b (Mus musculus)

Pain Link Frequency Relevance Heat long-term potentiation 12 98.84 Dopamine 120 97.40 Glutamate 31 97.36 Central nervous system 2 86.28 projection neuron 4 69.76 interneuron 1 65.92 imagery 8 23.84 Action potential 5 18.80 gABA 12 5.00 depression 9 5.00

Disease Link Frequency Relevance Heat Adhesions 2 49.68 Depression 9 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

LTP-inducing high-frequency stimulation has been reported to cause sustained DARPP-32 phosphorylation by PKA in a manner dependent on CaMKII in hippocampal slices (Atkins et al, 2005).

PKA Positive_regulation (cause) of Phosphorylation (phosphorylation) of DARPP-32 associated with long-term potentiation

1) Confidence 0.15 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0.13

Thus, model simulations suggest that PKA activation, phosphorylation of DARPP-32 at Thr34, and subsequent PP1 inhibition, produced by conjunctive glutamate and D1 receptor stimulation, can produce LTP by increased phosphorylation of AMPA receptors.

PKA Positive_regulation (activation) of Phosphorylation (phosphorylation) of DARPP-32 associated with glutamate and long-term potentiation

2) Confidence 0.11 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.74

General Comments

This test has worked.