INT19689

Context Info Confidence 0.24 First Reported 1983 Last Reported 2006 Negated 1 Speculated 1 Reported most in Abstract Documents 5 Total Number 6 Disease Relevance 1.01 Pain Relevance 2.76

nucleolus (Tes) plasma membrane (Tes) nucleus (Tes) protein complex (Tes) cytoplasm (Tes)

Anatomy Link Frequency sensory nerves 1 respiratory 1 Tes (Rattus norvegicus)

Pain Link Frequency Relevance Heat Antinociceptive 16 100.00 Nicotine 3 99.88 Endogenous opioid 1 99.80 gABA 3 99.32 Perioperative pain 5 97.36 qutenza 9 95.84 tetrodotoxin 4 95.12 analgesia 2 93.72 Opioid 1 85.44 tail-flick 2 82.80

Disease Link Frequency Relevance Heat Post Operative Pain 5 97.36 Nociception 4 86.48 Body Weight 2 82.92 Pain 3 67.76 Hypothermia 1 61.28 Anxiety Disorder 1 53.36 Increased Venous Pressure Under Development 1 52.08 Neurosis 3 50.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In a recently introduced clinically relevant rat model of TES we have validated and characterized the TES antinociceptive effect, suggesting involvement of the sensory nerves of the rat's scalp in mediating that effect.

Regulation (effect) of TES in sensory nerves associated with antinociceptive

1) Confidence 0.24 Published 2006 Journal Anesth. Analg. Section Abstract Doc Link 16717325 Disease Relevance 0.06 Pain Relevance 0.47

In this study we validated the TES antinociceptive effect in a novel animal model of cutaneously administered TES, when the stimulating conditions mimic the ones used in clinical practice.

Regulation (effect) of TES associated with antinociceptive

2) Confidence 0.24 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 14980928 Disease Relevance 0.09 Pain Relevance 0.45

It is supposed that endogenous opioid peptides regulate an afferent discharge on the level of sensory endings during TES.

Regulation (regulate) of TES associated with endogenous opioid

3) Confidence 0.24 Published 1990 Journal Biull Eksp Biol Med Section Abstract Doc Link 2083320 Disease Relevance 0 Pain Relevance 0.10

Before and after capsaicin treatment respiratory evaporative heat loss (REHL, w X kg-1), breathing frequency (BF, min-1) and metabolic heat production (M, w X kg-1) were determined in a warm environment (35-38 degrees C) as a function of core temperature, measured in the esophagus (Tes), which was altered by graded heat extraction with a colonic thermode.

Regulation (altered) of Tes in respiratory associated with qutenza

4) Confidence 0.20 Published 1986 Journal Pflugers Arch. Section Abstract Doc Link 3714439 Disease Relevance 0.36 Pain Relevance 0.53

The influence of transcutaneous electrical stimulation (TES) and psychological factors in determining the intensity of acute postoperative pain was examined in a prospective, double-blind controlled trial completed by 30 patients having elective surgery.

Spec (examined) Regulation (influence) of TES associated with perioperative pain

5) Confidence 0.18 Published 1983 Journal Pain Section Abstract Doc Link 6606153 Disease Relevance 0.50 Pain Relevance 0.56

In contrast, these compounds failed to affect TES-, nicotine- and GABA-induced relaxations.

Neg (failed) Regulation (affect) of TES associated with gaba and nicotine

6) Confidence 0.17 Published 1999 Journal J Auton Pharmacol Section Abstract Doc Link 10589974 Disease Relevance 0 Pain Relevance 0.65

General Comments

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