INT196956

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Context Info
Confidence 0.25
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.23
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Hmga2, Hdac1) DNA binding (Hmga2, Hdac1) nucleus (Hmga2, Hdac1)
transcription factor binding (Hmga2, Hdac1) nuclear chromosome (Hmga2) protein complex (Hdac1)
Hmga2 (Mus musculus)
Hdac1 (Mus musculus)
Pain Link Frequency Relevance Heat
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pituitary Cancer 27 86.48 High High
Targeted Disruption 11 74.28 Quite High
Cancer 3 73.72 Quite High
Retinoblastoma 2 23.08 Low Low
Adenoma 4 5.00 Very Low Very Low Very Low
Prolactinoma 3 5.00 Very Low Very Low Very Low
Repression 2 5.00 Very Low Very Low Very Low
Syndrome 1 5.00 Very Low Very Low Very Low
Headache 1 5.00 Very Low Very Low Very Low
Hypopituitarism 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using competitions with recombinant proteins and Chromatin Immonoprecipitation (ChIP) experiments, we demonstrated that following the binding of HMGA2 to pRB (Figure 2, step1), HDAC1 is displaced from the E2F1-target promoters (Figure 2, step 2) where it was recruited by pRB [34].
HMGA2 Binding (binding) of HDAC1
1) Confidence 0.25 Published 2006 Journal Cell Div Section Body Doc Link PMC1563461 Disease Relevance 0.23 Pain Relevance 0

General Comments

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