INT197372

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Context Info
Confidence 0.51
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 20
Disease Relevance 9.08
Pain Relevance 1.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neck 2
dendrites 2
lung 2
neutrophils 2
immune cell 1
Tmie (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 264 99.98 Very High Very High Very High
withdrawal 5 97.80 Very High Very High Very High
Inflammation 102 97.64 Very High Very High Very High
Pyramidal cell 21 95.20 Very High Very High Very High
cytokine 100 86.00 High High
fibrosis 30 81.44 Quite High
Hippocampus 27 80.96 Quite High
tetrodotoxin 9 80.00 Quite High
Action potential 3 66.24 Quite High
depression 3 64.32 Quite High
Disease Link Frequency Relevance Heat
Hypersensitivity Pneumonitis 700 99.84 Very High Very High Very High
INFLAMMATION 72 97.64 Very High Very High Very High
Osteoporotic Fractures 20 96.88 Very High Very High Very High
Osteoporosis 85 96.36 Very High Very High Very High
Postmenopausal Osteoporosis 25 96.20 Very High Very High Very High
Hypersensitivity 20 93.56 High High
Stress 12 92.40 High High
Apoptosis 50 90.32 High High
Frailty 15 89.60 High High
Arthritis 20 83.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The minimum dose at which SR was effective in preventing bone loss in early postmenopausal nonosteoporotic women and in the treatment of postmenopausal osteoporosis was 1 g per day and 2 g per day, respectively.20
Gene_expression (effective) of SR associated with postmenopausal osteoporosis
1) Confidence 0.51 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971725 Disease Relevance 0.18 Pain Relevance 0
SR is composed of two atoms of stable strontium and one molecule of ranelic acid.4 SR is a treatment for osteoporosis and unlike other drugs, has a dual effect on bone remodeling, being able to stimulate bone formation by osteoblasts, a property shared with bone-forming agents, and to inhibit bone resumption by osteoclasts, as antiresumptive agents.5,6
Gene_expression (composed) of SR in osteoclasts associated with osteoporosis
2) Confidence 0.38 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971725 Disease Relevance 0.48 Pain Relevance 0
Over a period of three years, in the SR group a baseline of 12.7% increase in BMD was observed in the lumbar spine, 7.2% in the femoral neck, and 8.6% in the total hip (P < 0.001 for all three comparisons with baseline values).21
Gene_expression (group) of SR in neck
3) Confidence 0.38 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971725 Disease Relevance 0.25 Pain Relevance 0
In TROPOS, at three years in the SR group a 5.7% baseline percentage increment in BMD was observed at the femoral neck and 7.1% at the total hip (P = 0.001), compared with the placebo group.22
Gene_expression (group) of SR in neck
4) Confidence 0.38 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971725 Disease Relevance 0.24 Pain Relevance 0
After treatment withdrawal, patients who switched to a placebo after four years experienced a significant reduction in BMD, showing how SR effects had been progressively reversible and reflecting the clearance of strontium from the bone.24

Bone turnover markers

Gene_expression (effects) of SR associated with withdrawal
5) Confidence 0.38 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971725 Disease Relevance 0.09 Pain Relevance 0.05
Seven days after the first SR antigen exposure, the immune cells in the lung tissues of B6 and Fc?
Gene_expression (exposure) of SR in lung
6) Confidence 0.34 Published 2010 Journal Immune Network Section Body Doc Link PMC2837154 Disease Relevance 0.55 Pain Relevance 0.12
Rs play a role in the development of HP, we administrated SR antigen intranasally to B6 and Fc?
Gene_expression (antigen) of SR associated with hypersensitivity pneumonitis
7) Confidence 0.34 Published 2010 Journal Immune Network Section Body Doc Link PMC2837154 Disease Relevance 0.54 Pain Relevance 0.12
Very recently, we reported that CD4+CD25+ regulatory T (Treg) cells attenuate SR-induced HP by suppressing IFN-?
Gene_expression (attenuate) of SR associated with hypersensitivity pneumonitis
8) Confidence 0.34 Published 2010 Journal Immune Network Section Body Doc Link PMC2837154 Disease Relevance 0.46 Pain Relevance 0
Moreover, in several studies using the SR-induced murine HP model, SR-spedific serum IgG or IL-2 production of BAL cells was measured to evaluate the adaptive immune responses in SR-induced HP (38,39).
Gene_expression (production) of SR associated with hypersensitivity pneumonitis
9) Confidence 0.30 Published 2010 Journal Immune Network Section Body Doc Link PMC2837154 Disease Relevance 0.74 Pain Relevance 0.06
Therefore, to examine adaptive immune responses, we measured the SR-specific immune cell proliferation and the IgG levels both in sera and BALF.
Gene_expression (levels) of SR in immune cell
10) Confidence 0.30 Published 2010 Journal Immune Network Section Body Doc Link PMC2837154 Disease Relevance 0.63 Pain Relevance 0.03
R-deficient and B6 mice during SR-induced hypersensitivity pneumonitis
Gene_expression (deficient) of SR associated with hypersensitivity pneumonitis
11) Confidence 0.30 Published 2010 Journal Immune Network Section Body Doc Link PMC2837154 Disease Relevance 0.48 Pain Relevance 0.12
R-/- mice upon SR antigen exposure, resulting in similar adaptive immune responses between Fc?
Gene_expression (exposure) of SR
12) Confidence 0.30 Published 2010 Journal Immune Network Section Body Doc Link PMC2837154 Disease Relevance 0.41 Pain Relevance 0.04
in the lungs during SR-induced HP, significantly increased in BALF of Fc?
Gene_expression (during) of SR in lungs associated with hypersensitivity pneumonitis
13) Confidence 0.30 Published 2010 Journal Immune Network Section Body Doc Link PMC2837154 Disease Relevance 0.91 Pain Relevance 0.03
production by neutrophils during SR-induced HP.
Gene_expression (production) of SR in neutrophils associated with hypersensitivity pneumonitis
14) Confidence 0.30 Published 2010 Journal Immune Network Section Body Doc Link PMC2837154 Disease Relevance 0.86 Pain Relevance 0.08
produced by neutrophils during SR-induced HP.
Gene_expression (produced) of SR in neutrophils associated with hypersensitivity pneumonitis
15) Confidence 0.30 Published 2010 Journal Immune Network Section Body Doc Link PMC2837154 Disease Relevance 0.91 Pain Relevance 0.07
The cause of differences in LTP expression across SR levels may stem from a greater propensity of proximal dendrites to generate dendritic spikes.
Gene_expression (expression) of SR in dendrites associated with long-term potentiation
16) Confidence 0.15 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1574331 Disease Relevance 0.06 Pain Relevance 0.48
The cause of differences in LTP expression across SR levels may stem from a greater propensity of proximal dendrites to generate dendritic spikes.
Gene_expression (levels) of SR in dendrites associated with long-term potentiation
17) Confidence 0.15 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1574331 Disease Relevance 0.06 Pain Relevance 0.47
Applying baseline stimulation and subsequently TBS through one of the electrodes situated in the mid-distal part of SR on the border between CA1 and CA3 areas, we demonstrated that the largest potentiation of fEPSPs occurred in proximal dendritic sites within 50–80 ?
Gene_expression (part) of SR in proximal
18) Confidence 0.15 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1574331 Disease Relevance 0.06 Pain Relevance 0.23
-adrenergic receptor blockers,43,44 and further studies are required to validate the transcription mechanism regulating the expression of SR genes by thiopental.45
Gene_expression (expression) of SR
19) Confidence 0.02 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2824862 Disease Relevance 0.67 Pain Relevance 0
Several studies have shown that expression of SR genes was increased by antioxidants and ?
Gene_expression (expression) of SR
20) Confidence 0.02 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2824862 Disease Relevance 0.51 Pain Relevance 0

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