INT19747

Context Info Confidence 0.46 First Reported 1990 Last Reported 2010 Negated 3 Speculated 2 Reported most in Body Documents 14 Total Number 16 Disease Relevance 4.67 Pain Relevance 1.68

extracellular space (Egf) plasma membrane (Egf)

Anatomy Link Frequency uterine 3 posterior 1 interneurons 1 neuronal 1 uterus 1 Egf (Rattus norvegicus)

Pain Link Frequency Relevance Heat narcan 2 100.00 Nerve growth factor 42 99.92 Opioid 5 99.84 tetrodotoxin 1 99.44 Calcitonin gene-related peptide 22 98.12 chemokine 2 95.92 cINOD 1 95.60 cytokine 40 95.32 Inflammation 42 94.92 qutenza 4 94.48

Disease Link Frequency Relevance Heat Shock 4 99.28 Rheumatoid Arthritis 14 98.84 Injury 104 98.48 Adhesions 9 98.08 Ulcers 4 96.60 Hepatocellular Cancer 89 96.40 INFLAMMATION 46 94.92 Dysmenorrhea 6 94.36 Schizophrenia 441 90.16 Congenital Anomalies 88 86.48

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The contractile action of EGF, which was not abolished by the removal of extracellular calcium, was not affected by atropine, tetrodotoxin, phentolamine and indomethacin.

Neg (not) Regulation (affected) of EGF associated with tetrodotoxin

1) Confidence 0.46 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2086243 Disease Relevance 0 Pain Relevance 0.10

The aim of this work was to study the effect of the in vivo administration of EGF on uterine contractility, prostaglandin production and timing of parturition in rats.

Regulation (effect) of EGF in uterine

2) Confidence 0.45 Published 2003 Journal Reproduction Section Abstract Doc Link 14525528 Disease Relevance 0.09 Pain Relevance 0.09

Effects of in vivo administration of epidermal growth factor (EGF) on uterine contractility, prostaglandin production and timing of parturition in rats.

Regulation (Effects) of epidermal growth factor in uterine

3) Confidence 0.45 Published 2003 Journal Reproduction Section Title Doc Link 14525528 Disease Relevance 0.09 Pain Relevance 0.09

Effects of in vivo administration of epidermal growth factor (EGF) on uterine contractility, prostaglandin production and timing of parturition in rats.

Regulation (Effects) of EGF in uterine

4) Confidence 0.45 Published 2003 Journal Reproduction Section Title Doc Link 14525528 Disease Relevance 0.09 Pain Relevance 0.09

We examined the protective and vasodilatory effects of EGF on the gastric mucosa and its interaction with sensory nerves, CGRP, and nitric oxide (NO) in anesthetized rats.

Spec (examined) Regulation (effects) of EGF in sensory nerves associated with calcitonin gene-related peptide

5) Confidence 0.39 Published 2001 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 11292598 Disease Relevance 0 Pain Relevance 0.35

Epidermal growth factor influenced by opioid peptides in immature rat uterus.

Regulation (influenced) of Epidermal growth factor in uterus associated with narcan and opioid

6) Confidence 0.27 Published 2000 Journal J. Endocrinol. Invest. Section Title Doc Link 11021765 Disease Relevance 0 Pain Relevance 0.24

Subsequent studies found similar effects of EGF and EPO treatments on more posterior injuries.

Regulation (effects) of EGF in posterior associated with injury

7) Confidence 0.25 Published 2010 Journal Frontiers in Human Neuroscience Section Body Doc Link PMC2991189 Disease Relevance 0.24 Pain Relevance 0

To determine the posttranscriptional target of EGF’s action in elevating the KOR level, we examined Grb7, a previously identified KOR mRNA–binding protein that recognizes its 5?

Spec (determine) Regulation (target) of EGF

8) Confidence 0.22 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2819679 Disease Relevance 0.16 Pain Relevance 0.12

The concentration of EGF in saliva was not affected by mucosal damage or H. pylori infection.

Neg (not) Regulation (affected) of EGF in saliva

9) Confidence 0.16 Published 2001 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 11552919 Disease Relevance 0.16 Pain Relevance 0

The literature supports the hypothesis of EGF regulation of tight junction function, however there is ambiguity as to weather EGF activation improves or impairs barrier function [41], [42].

Regulation (regulation) of EGF

10) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892473 Disease Relevance 0.19 Pain Relevance 0.03

It was found, however, that various EGF autocrine systems operate at a ratio of ligand : receptor production rates much smaller than 0.2 (388), indicating that EGF-R autocrine systems are regulated primarily through ligand availability and capture and not through regulation of receptor number.

Neg (not) Regulation (regulated) of EGF-R

11) Confidence 0.11 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0

The expression of several EGF family members, specifically EGF, TGF-?

Regulation (several) of EGF

12) Confidence 0.08 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721397 Disease Relevance 0.78 Pain Relevance 0.06

Embryonic ERbeta modulates EGF that influences calretinin-immunoreactive GABEergic interneurons and neuronal migration.260 This would suggest that estrogenic disruption involving ERbeta would alter EGF.

Regulation (alter) of EGF in neuronal

13) Confidence 0.06 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 0.88 Pain Relevance 0.05

Controlled media containing DMEM, B27, N2, BDNF, EGF, nerve growth factor (NGF), RA, dBcAMP, collagen and fibronectin have also showed success.

Regulation (Controlled) of EGF in nerve associated with nerve growth factor and rheumatoid arthritis

14) Confidence 0.05 Published 2010 Journal Surgical Neurology International Section Body Doc Link PMC3019362 Disease Relevance 0.23 Pain Relevance 0.10

Since 1998, 107 papers were published, clarifying further effects of rebamipide on cyclooxygenase-2, prostaglandin E receptors, growth factors (i.e., HGF, EGF, and VEGF), heat-shock proteins, nitric oxide, adhesion molecules, neutrophils, and Helicobacter pylori- and NSAID-related pathology.

Regulation (effects) of EGF in neutrophils associated with ulcers, shock, cinod and adhesions

15) Confidence 0.03 Published 2005 Journal Dig. Dis. Sci. Section Abstract Doc Link 16184418 Disease Relevance 0.86 Pain Relevance 0.31

Embryonic ERbeta modulates EGF that influences calretinin-immunoreactive GABEergic interneurons and neuronal migration.260 This would suggest that estrogenic disruption involving ERbeta would alter EGF.

Regulation (alter) of EGF in interneurons

16) Confidence 0.02 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 0.88 Pain Relevance 0.05

General Comments

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