INT197499

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Context Info
Confidence 0.14
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.54
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Apoe, Tfrc) endosome (Tfrc) mitochondrion (Tfrc)
transport (Apoe) aging (Apoe) Golgi apparatus (Apoe)
Anatomy Link Frequency
neurons 2
Apoe (Mus musculus)
Tfrc (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 4 88.32 High High
Pyramidal cell 12 20.44 Low Low
Intracerebroventricular 32 5.00 Very Low Very Low Very Low
Hippocampus 14 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
dorsal root ganglion 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 4 88.32 High High
Brain Injury 6 84.92 Quite High
Disease 38 68.72 Quite High
Viral Meningitis 4 55.44 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 4 54.92 Quite High
Motor Neuron Diseases 10 53.60 Quite High
Disorder Of Lipid Metabolism 8 50.00 Quite Low
Death 2 23.56 Low Low
Targeted Disruption 8 5.00 Very Low Very Low Very Low
Drug Induced Neurotoxicity 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have recently published that microglia from targeted replacement (TR) mice that express "humanized" apoE show isoform-dependent innate immune activation from CD14/TLR4 activation and paracrine damage to neurons in mixed primary cultures and hippocampal slices that is least with TR APOE2, intermediate with TR APOE3, and greatest with TR APOE4; these apoE isoform-dependent differences in paracrine damage to neurons are p38MAPK-dependent [39].
APOE3 Binding (intermediate) of TR in neurons
1) Confidence 0.14 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1584222 Disease Relevance 0.77 Pain Relevance 0.09
We have recently published that microglia from targeted replacement (TR) mice that express "humanized" apoE show isoform-dependent innate immune activation from CD14/TLR4 activation and paracrine damage to neurons in mixed primary cultures and hippocampal slices that is least with TR APOE2, intermediate with TR APOE3, and greatest with TR APOE4; these apoE isoform-dependent differences in paracrine damage to neurons are p38MAPK-dependent [39].
APOE2 Binding (intermediate) of TR in neurons
2) Confidence 0.14 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1584222 Disease Relevance 0.77 Pain Relevance 0.09

General Comments

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