INT197554

Context Info Confidence 0.02 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.86 Pain Relevance 0

cell adhesion (ITGA4) plasma membrane (ITGA4)

ITGA4 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 2 5.00 palliative 1 5.00 Glutamate 1 5.00

Disease Link Frequency Relevance Heat Cancer 104 95.28 Lung Cancer 54 85.84 Non-small-cell Lung Cancer 24 84.36 Death 2 72.24 Stress 8 66.44 Targeted Disruption 1 56.56 Adenocarcinoma 7 33.40 Malignant Neoplastic Disease 4 5.00 Nicotine Addiction 3 5.00 Apoptosis 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Expression of the wild-type KEAP1 in H838 cells stably expressing an ARE reporter completely abolished ARE reporter activity, whereas overexpression of the KEAP1 mutant construct did not, suggesting that the somatic mutations hamper the association between KEAP1 and NRF2 and consequently activate NRF2.

Negative_regulation (abolished) of Gene_expression (Expression) of wild-type

1) Confidence 0.02 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1584412 Disease Relevance 0.86 Pain Relevance 0

General Comments

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