INT197652

Context Info Confidence 0.02 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.47 Pain Relevance 0.08

nucleoplasm (NR1I2) signal transduction (NR1I2) nucleus (NR1I2)

NR1I2 (Homo sapiens) CYP2A (Homo sapiens)

Pain Link Frequency Relevance Heat carbamazepine 17 85.52 antiepileptic Drug 1 50.00 anticonvulsant 2 5.00 cytokine 1 5.00 Lamotrigine 1 5.00 Pain 1 5.00 alcohol 1 5.00 antidepressant 1 5.00 cva 1 5.00

Disease Link Frequency Relevance Heat Osteoporosis 31 87.92 Hypercalcemia 15 83.32 Hypophosphatemia 3 71.64 Hypocalcemia 8 70.92 Epilepsy 27 5.00 Bone Cancer 10 5.00 Rickets 6 5.00 Convulsion 6 5.00 Stress 4 5.00 Sunburn 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

PXR has been shown to mediate induction of CYP 2 and CYP 3, the cytochrome P450 enzymes involved in the drug metabolism.

PXR Positive_regulation (mediate) of Positive_regulation (induction) of CYP 2

1) Confidence 0.02 Published 2006 Journal Nutr Metab (Lond) Section Body Doc Link PMC1586194 Disease Relevance 0.47 Pain Relevance 0.08

General Comments

This test has worked.