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Context Info
Confidence 0.36
First Reported 1980
Last Reported 2011
Negated 5
Speculated 0
Reported most in Abstract
Documents 41
Total Number 41
Disease Relevance 8.80
Pain Relevance 5.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Dbi) transport (Dbi) mitochondrion (Dbi)
extracellular space (Dbi) plasma membrane (Dbi) nucleus (Dbi)
Anatomy Link Frequency
liver 3
lung 3
brain 2
tail 1
neurons 1
Dbi (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 34 100.00 Very High Very High Very High
Opioid 20 100.00 Very High Very High Very High
gABA 2 99.96 Very High Very High Very High
Kinase C 61 99.28 Very High Very High Very High
Potency 33 98.82 Very High Very High Very High
Dynorphin 22 98.68 Very High Very High Very High
tail-flick 8 97.68 Very High Very High Very High
Inflammation 75 97.20 Very High Very High Very High
Pain 7 96.48 Very High Very High Very High
GABAergic 1 96.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 143 98.12 Very High Very High Very High
INFLAMMATION 90 97.20 Very High Very High Very High
Meningoencephalitis 6 96.92 Very High Very High Very High
Infection 147 96.68 Very High Very High Very High
Pain 5 96.48 Very High Very High Very High
Erythema 1 96.12 Very High Very High Very High
Cancer 117 95.40 Very High Very High Very High
Death 18 93.84 High High
Non-small-cell Lung Cancer 16 93.48 High High
Reprotox - General 1 6 91.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Third, the immunoreactive labeled beta-EP (125I-beta-EP), which was purified on a Sephadex G-50 column and did not specifically bind to the rat brain membranes, did not accumulate in the lung and liver and was not displaced by unlabeled beta-EP in vivo, in contrast to [125I-Tyr27]beta-EP, the commercially available HPLC-purified labeled peptide.
beta-EP Neg (not) Binding (bind) of in lung
1) Confidence 0.36 Published 1988 Journal Biochem. Pharmacol. Section Abstract Doc Link 2837232 Disease Relevance 0 Pain Relevance 0.24
Specific binding of human beta-endorphin (beta-EP) was demonstrated in the lung and liver of the rat in vivo by the following lines of evidence, using [125I-Tyr27]beta-EP as a radiolabeled tracer.
beta-EP Binding (binding) of in liver
2) Confidence 0.36 Published 1988 Journal Biochem. Pharmacol. Section Abstract Doc Link 2837232 Disease Relevance 0 Pain Relevance 0
Diazepam binding inhibitor (DBI), a peptide located in CNS neurons, blocks the binding of benzodiazepines and beta-carbolines to the allosteric modulatory sites of gamma-aminobutyric acid (GABAA) receptors.
DBI Binding (binding) of in neurons
3) Confidence 0.36 Published 1987 Journal J. Neurochem. Section Abstract Doc Link 3819722 Disease Relevance 0 Pain Relevance 0
Third, the immunoreactive labeled beta-EP (125I-beta-EP), which was purified on a Sephadex G-50 column and did not specifically bind to the rat brain membranes, did not accumulate in the lung and liver and was not displaced by unlabeled beta-EP in vivo, in contrast to [125I-Tyr27]beta-EP, the commercially available HPLC-purified labeled peptide.
beta-EP Neg (not) Binding (bind) of in lung
4) Confidence 0.32 Published 1988 Journal Biochem. Pharmacol. Section Abstract Doc Link 2837232 Disease Relevance 0 Pain Relevance 0.24
Dbi binds GABA(A) receptors with high affinity [42], [43], and it is thought that suppression of GABAergic signaling is one mechanism through which Dbi modulates retinal neurotransmission, particularly in the inner plexiform layer [40], [41], [44], which further increases following activity-dependent phosphorylation [45], which is a hallmark of diabetes-related retinal pathology [46].
Dbi Binding (binds) of in inner plexiform layer associated with gaba, diabetes mellitus and gabaergic
5) Confidence 0.30 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020973 Disease Relevance 0.42 Pain Relevance 0.15
The present study compares the potencies of D-Ala2-D-Leu5-enkephalin (DADL) and beta-endorphin (beta-EP) injection intrathecally and i.c.v. on the inhibition of tail-flick and ice water-induced shaking responses in pentobarbital-anesthetized rats.
beta-EP Binding (potencies) of in tail associated with tail-flick and enkephalin
6) Confidence 0.28 Published 1983 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6294283 Disease Relevance 0 Pain Relevance 0.66
Due to targeting a one cell layer with AS-ODN, immunoblotting was not an ideal method for studying G?
ODN Binding (targeting) of
7) Confidence 0.23 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1855344 Disease Relevance 0.26 Pain Relevance 0.08
i2 immunostaining in ODN and saline control groups was identical with both antibodies.
ODN Binding (immunostaining) of
8) Confidence 0.23 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1855344 Disease Relevance 0 Pain Relevance 0
Brain cannulated rats were injected with the opioid peptide beta-endorphin (beta-EP) directly into the hypothalamic paraventricular nucleus (PVN) where norepinephrine (NE) is most effective in stimulating eating behavior.
beta-EP Binding (injected) of in nucleus associated with opioid
9) Confidence 0.21 Published 1982 Journal Peptides Section Abstract Doc Link 6289281 Disease Relevance 0 Pain Relevance 0.28
Binding of human beta-endorphin (beta-EP) to rat renal basolateral membranes was characterized using [125I]Tyr27-beta-EP ([125I]beta-EP) as a primary ligand.
beta-EP Binding (Binding) of
10) Confidence 0.18 Published 1990 Journal Chem. Pharm. Bull. Section Abstract Doc Link 2092936 Disease Relevance 0 Pain Relevance 0
Moreover, a 50% inhibition by 10 microM of dynorphin(1-13) suggests that a certain region of the primary structure of beta-EP, excluding at least the NH2-terminal enkephalin sequence, is of particular importance for the [125I]beta-EP binding.
beta-EP Binding (binding) of associated with dynorphin and enkephalin
11) Confidence 0.18 Published 1990 Journal Chem. Pharm. Bull. Section Abstract Doc Link 2092936 Disease Relevance 0 Pain Relevance 0.61
This has been difficult to achieve due to the lack of availability of 3H-beta-EP and to technical difficulties associated with high non-specific binding of beta-EP.
beta-EP Binding (binding) of
12) Confidence 0.16 Published 1980 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6256172 Disease Relevance 0 Pain Relevance 0.34
Third, the immunoreactive labeled beta-EP (125I-beta-EP), which was purified on a Sephadex G-50 column and did not specifically bind to the rat brain membranes, did not accumulate in the lung and liver and was not displaced by unlabeled beta-EP in vivo, in contrast to [125I-Tyr27]beta-EP, the commercially available HPLC-purified labeled peptide.
beta-EP Neg (not) Binding (bind) of in liver
13) Confidence 0.12 Published 1988 Journal Biochem. Pharmacol. Section Abstract Doc Link 2837232 Disease Relevance 0 Pain Relevance 0.24
Specific binding of human beta-endorphin (beta-EP) was demonstrated in the lung and liver of the rat in vivo by the following lines of evidence, using [125I-Tyr27]beta-EP as a radiolabeled tracer.
beta-EP Binding (binding) of in lung
14) Confidence 0.12 Published 1988 Journal Biochem. Pharmacol. Section Abstract Doc Link 2837232 Disease Relevance 0 Pain Relevance 0
Third, the immunoreactive labeled beta-EP (125I-beta-EP), which was purified on a Sephadex G-50 column and did not specifically bind to the rat brain membranes, did not accumulate in the lung and liver and was not displaced by unlabeled beta-EP in vivo, in contrast to [125I-Tyr27]beta-EP, the commercially available HPLC-purified labeled peptide.
beta-EP Neg (not) Binding (bind) of in liver
15) Confidence 0.11 Published 1988 Journal Biochem. Pharmacol. Section Abstract Doc Link 2837232 Disease Relevance 0 Pain Relevance 0.24
The binding of tritiated beta-endorphin (3H-beta-EP) to brain homogenates is described.
beta-EP Binding (binding) of in brain
16) Confidence 0.11 Published 1980 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6256172 Disease Relevance 0 Pain Relevance 0.23
We now report that 3H-beta-EP binding is saturable, stereospecific, has high affinity and is inhibited by sodium.
beta-EP Binding (binding) of
17) Confidence 0.11 Published 1980 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6256172 Disease Relevance 0 Pain Relevance 0.35
As shown in Figure 6b, mice treated with CpG ODN fma1555 (50 ?
CpG ODN Binding (treated) of
18) Confidence 0.07 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1156963 Disease Relevance 0.80 Pain Relevance 0
Mice were also treated with a combination of CpG ODN fma1555 (25 ?
CpG ODN Binding (combination) of
19) Confidence 0.07 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1156963 Disease Relevance 0.65 Pain Relevance 0
Purified CpG ODN fma1555, CpG ODN 1555 and ODN fma1556 were assayed for endotoxins using the Limulus amebocyte lysate assay and were found to contain <0.1 endotoxin unit per mg of oligonucleotide.


CpG ODN Binding (found) of
20) Confidence 0.07 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1156963 Disease Relevance 0.14 Pain Relevance 0.06

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