INT1978

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Context Info
Confidence 0.58
First Reported 1979
Last Reported 1996
Negated 2
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.58
Pain Relevance 3.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Maoa) oxidoreductase activity (Maoa)
Anatomy Link Frequency
brain 2
Maoa (Rattus norvegicus)
Pain Link Frequency Relevance Heat
monoamine 13 100.00 Very High Very High Very High
Desipramine 10 99.80 Very High Very High Very High
antidepressant 8 98.38 Very High Very High Very High
withdrawal 4 97.74 Very High Very High Very High
fluoxetine 17 96.36 Very High Very High Very High
Serotonin 4 95.68 Very High Very High Very High
Dopamine 14 90.04 High High
depression 2 85.68 High High
Hippocampus 3 83.92 Quite High
noradrenaline 1 81.92 Quite High
Disease Link Frequency Relevance Heat
Depression 2 85.68 High High
Sprains And Strains 8 76.48 Quite High
Congenital Anomalies 2 66.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of MAO-B in 1:8 homogenates was modest (12%) and was not significantly reduced by homogenate dilution.
Neg (not) Negative_regulation (reduced) of Negative_regulation (Inhibition) of MAO
1) Confidence 0.58 Published 1996 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8832583 Disease Relevance 0 Pain Relevance 0.81
Chronic treatment with the MAO-B inhibitors reduced striatal MAO-B activity by 90%, with 15% (TVP-1012) or 40% (deprenyl) inhibition of MAO-A.
Negative_regulation (reduced) of Negative_regulation (inhibition) of MAO-A
2) Confidence 0.42 Published 1996 Journal J. Neurochem. Section Abstract Doc Link 8858937 Disease Relevance 0 Pain Relevance 0.45
To explore the interaction between circadian rhythmicity, behavioral state, and monoaminergic systems, the present study investigated the effects of chronic administration and withdrawal of the following antidepressant agents on circadian wheel-running rhythms of laboratory rats: a) moclobemide, a reversible and selective monoamine oxidase (MAO) type A inhibitor; b) Ro 19-6327, a selective MAO type B inhibitor; c) desipramine, a preferential norepinephrine reuptake inhibitor; d) clomipramine and e) fluoxetine, both serotonin reuptake inhibitors; and f) levoprotiline, an atypical antidepressant whose biochemical mechanism is still unknown.
Negative_regulation (inhibitor) of Negative_regulation (inhibitor) of MAO associated with desipramine, antidepressant, serotonin, withdrawal, fluoxetine and monoamine
3) Confidence 0.41 Published 1992 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 1438492 Disease Relevance 0.30 Pain Relevance 0.58
To explore the interaction between circadian rhythmicity, behavioral state, and monoaminergic systems, the present study investigated the effects of chronic administration and withdrawal of the following antidepressant agents on circadian wheel-running rhythms of laboratory rats: a) moclobemide, a reversible and selective monoamine oxidase (MAO) type A inhibitor; b) Ro 19-6327, a selective MAO type B inhibitor; c) desipramine, a preferential norepinephrine reuptake inhibitor; d) clomipramine and e) fluoxetine, both serotonin reuptake inhibitors; and f) levoprotiline, an atypical antidepressant whose biochemical mechanism is still unknown.
Negative_regulation (inhibitor) of Negative_regulation (reversible) of MAO associated with desipramine, antidepressant, serotonin, withdrawal, fluoxetine and monoamine
4) Confidence 0.41 Published 1992 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 1438492 Disease Relevance 0.29 Pain Relevance 0.55
However, chlorimipramine failed to reduce the rate of 5-HT accumulation after monoamine oxidase inhibition.
Neg (failed) Negative_regulation (reduce) of Negative_regulation (inhibition) of monoamine oxidase associated with monoamine
5) Confidence 0.41 Published 1979 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 311440 Disease Relevance 0 Pain Relevance 0.38
Long-term 5-HT reuptake blockade, but not monoamine oxidase inhibition, decreases the function of terminal 5-HT autoreceptors: an electrophysiological study in the rat brain.
Negative_regulation (decreases) of Negative_regulation (inhibition) of monoamine oxidase in brain associated with monoamine
6) Confidence 0.31 Published 1988 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 3260661 Disease Relevance 0 Pain Relevance 0.34

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