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Context Info
Confidence 0.67
First Reported 1990
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 15
Total Number 18
Disease Relevance 4.81
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Hprt) transferase activity, transferring glycosyl groups (Hprt) cytoplasm (Hprt)
Anatomy Link Frequency
cornea 2
band 1
kidney 1
Hprt (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 35 100.00 Very High Very High Very High
cytokine 77 93.04 High High
Glutamate receptor 11 69.24 Quite High
Hippocampus 11 63.96 Quite High
GABAergic 12 60.32 Quite High
imagery 106 50.00 Quite Low
Inflammation 60 50.00 Quite Low
Morphine 58 50.00 Quite Low
Opioid 23 50.00 Quite Low
Ventral tegmentum 5 43.24 Quite Low
Disease Link Frequency Relevance Heat
Hyperuricemia 38 99.64 Very High Very High Very High
Injury 66 99.54 Very High Very High Very High
Sprains And Strains 88 99.36 Very High Very High Very High
Keratitis 39 99.16 Very High Very High Very High
Corneal Neovascularization 6 98.56 Very High Very High Very High
Disease 289 97.68 Very High Very High Very High
Aspergillus Infection 9 95.40 Very High Very High Very High
Neurologic Manifestations 7 94.92 High High
Candida Infection 9 94.40 High High
Infection 6 93.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A strain of mice with an experimentally produced mutation at the HPRT locus showed some residual 'apparent HPRT activity' in brain, liver, testicular, splenic, kidney and ovarian tissues but not in erythrocyte haemolysates.
Gene_expression (produced) of HPRT in kidney associated with sprains and strains
1) Confidence 0.67 Published 1990 Journal Enzyme Section Abstract Doc Link 2095336 Disease Relevance 0.72 Pain Relevance 0.08
Expression of hypoxanthine guanine phosphoribosyl transferase 1 (Hprt1) transcript with stable level between four strains was quantified to control for variation in cDNA amounts.
Gene_expression (Expression) of Hprt1 associated with sprains and strains
2) Confidence 0.65 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1553451 Disease Relevance 0.10 Pain Relevance 0.03
Expression of 8 HKGs (glyceraldehyde-3-phosphate dehydrogenase [GAPDH], beta-actin [ACTB], lactate dehydrogenase A [LDHA], ribosomal protein L5 [RPL5], ubiquitin C [UBC], peptidylprolyl isomerase A [PPIA], TATA-box binding protein [TBP1], and hypoxanthine guanine phosphoribosyl transferase [HPRT1]) in the cornea were measured at various time points by microarray hybridization or qRT–PCR and the data analyzed using geNorm and NormFinder.


Spec (analyzed) Gene_expression (Expression) of HPRT1 in cornea
3) Confidence 0.57 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2893048 Disease Relevance 0.84 Pain Relevance 0
In this paper, we establish models of experimental corneal neovascularization (CorNV), fungal keratitis (FK) and corneal wound in mice and study the expression patterns of three traditional HKGs (ACTB, lactate dehydrogenase [LDHA], and GAPDH), five new HKGs (ubiquitin C [UBC] [14], peptidylprolyl isomerase A [PPIA] [15], TATA-box binding protein [TBP] [16], hypoxanthine guanine phosphoribosyl transferase [HPRT1] [17], and ribosomal protein L5 [RPL5] [18]).
Gene_expression (expression) of hypoxanthine guanine phosphoribosyl transferase associated with corneal neovascularization, injury and keratitis
4) Confidence 0.57 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2893048 Disease Relevance 0.40 Pain Relevance 0.04
Expression of 8 HKGs (glyceraldehyde-3-phosphate dehydrogenase [GAPDH], beta-actin [ACTB], lactate dehydrogenase A [LDHA], ribosomal protein L5 [RPL5], ubiquitin C [UBC], peptidylprolyl isomerase A [PPIA], TATA-box binding protein [TBP1], and hypoxanthine guanine phosphoribosyl transferase [HPRT1]) in the cornea were measured at various time points by microarray hybridization or qRT–PCR and the data analyzed using geNorm and NormFinder.


Spec (analyzed) Gene_expression (Expression) of hypoxanthine guanine phosphoribosyl transferase in cornea
5) Confidence 0.57 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2893048 Disease Relevance 0.84 Pain Relevance 0
The difference between HPRT-related neurological dysfunction and HPRT-related hyperuricaemia groups was not significant (P = 0.56).


Gene_expression (dysfunction) of HPRT associated with hyperuricemia and anesthesia
6) Confidence 0.46 Published 2010 Journal Brain Section Body Doc Link PMC2842514 Disease Relevance 0.56 Pain Relevance 0.27
The difference between HPRT-related neurological dysfunction and HPRT-related hyperuricaemia groups was not significant (P = 0.56).


Gene_expression (dysfunction) of HPRT associated with hyperuricemia and anesthesia
7) Confidence 0.46 Published 2010 Journal Brain Section Body Doc Link PMC2842514 Disease Relevance 0.57 Pain Relevance 0.28
First and foremost, the differences in gene expression were calculated with reference to the ubiquitously expressed HPRT.
Gene_expression (expressed) of HPRT
8) Confidence 0.45 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1544347 Disease Relevance 0.08 Pain Relevance 0.06
Hprt is a ubiquitously expressed locus, ensuring minimal variation in expression levels of the reporter in cells so that analyses can be made both at the systems and single-cell level.
Gene_expression (expressed) of Hprt
9) Confidence 0.43 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1991622 Disease Relevance 0.18 Pain Relevance 0
Hprt is a ubiquitously expressed locus, ensuring minimal variation in expression levels of the reporter in cells so that analyses can be made both at the systems and single-cell level.
Gene_expression (expressed) of Hprt
10) Confidence 0.37 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1991622 Disease Relevance 0.18 Pain Relevance 0
Naloxone reverses the effect of morphine on enhancement of XD/XO gene expression and cannot reverse the inhibitory effect of morphine on HGPRT and AK gene expression.


Gene_expression (expression) of HGPRT
11) Confidence 0.35 Published 2003 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 12757645 Disease Relevance 0 Pain Relevance 0
CONCLUSION: The downregulation effect of morphine on the gene expression of AK and HGPRT may not be mediated by mu receptor.
Gene_expression (expression) of HGPRT
12) Confidence 0.35 Published 2003 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 12757645 Disease Relevance 0 Pain Relevance 0
The mRNA expression level of each gene was determined in Excel by using the comparative 2-(delta delta Cq) method and normalized to the geometric mean of the stably-expressed reference genes GAPDH, SDHA and HPRT as determined by geNorm [50].
Gene_expression (expressed) of HPRT
13) Confidence 0.33 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 0 Pain Relevance 0
most stable housekeeping genes—HPRT, SDHA, and ?
Gene_expression (housekeeping) of HPRT
14) Confidence 0.29 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2233768 Disease Relevance 0 Pain Relevance 0.13
most stable housekeeping genes—HPRT, SDHA, and ?
Gene_expression (stable) of HPRT
15) Confidence 0.29 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2233768 Disease Relevance 0 Pain Relevance 0.13
Copy number for each molecule (all P2X subunits and Lyn tyrosine kinase) was determined based on comparisons to standard curves, and for each sample, the copy number for each molecule was normalized to the expression of the endogenous housekeeping gene hypoxanthine phosphoribosyl transferase (HPRT).


Gene_expression (expression) of HPRT
16) Confidence 0.28 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2847917 Disease Relevance 0 Pain Relevance 0
The results revealed that in comparison to the low-abundant endogenous control gene Hprt, Mcph1 is expressed at very low levels in all analyzed tissues.
Spec (analyzed) Gene_expression (expressed) of Hprt
17) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821930 Disease Relevance 0 Pain Relevance 0
PCR amplification was performed for HPRT, IFN-gamma and IL-4 cytokines and the intensity of each band was measured by densitometry and normalized against HPRT expression as a house keeping gene.
Gene_expression (expression) of HPRT in band
18) Confidence 0.15 Published 2010 Journal Indian J Med Microbiol Section Body Doc Link 20061762 Disease Relevance 0.36 Pain Relevance 0

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