INT198047

Context Info Confidence 0.43 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.77 Pain Relevance 0

cell differentiation (MCL1) nucleoplasm (MCL1) mitochondrion (MCL1) nucleus (MCL1) cytoplasm (MCL1)

MCL1 (Homo sapiens)

Pain Link Frequency Relevance Heat palliative 2 5.00

Disease Link Frequency Relevance Heat Carcinoma 94 99.96 Apoptosis 108 88.72 Hepatocellular Cancer 9 72.64 Cancer 21 5.00 Death 7 5.00 Leukemia 4 5.00 Targeted Disruption 4 5.00 Multiple Myeloma 3 5.00 Lung Cancer 3 5.00 Lymphatic System Cancer 2 5.00

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This study demonstrates that targeting of Mcl-1 by siRNA sensitizes HCC cell lines to chemotherapy and molecularly targeted therapy.

Regulation (sensitizes) of Positive_regulation (targeting) of Mcl-1 associated with carcinoma

1) Confidence 0.43 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.77 Pain Relevance 0

General Comments

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