INT198148

Context Info Confidence 0.00 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 0.96 Pain Relevance 0

molecular_function (Tm2d2) cellular_component (Tm2d2) biological_process (Tm2d2)

Tm2d2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat addiction 2 5.00 anesthesia 2 5.00

Disease Link Frequency Relevance Heat Bacillus Anthracis Infection 34 90.88 Poisoning 38 81.36 Death 20 72.08 Disease 6 69.92 Cancer 6 5.00 Pressure And Volume Under Development 4 5.00 Diphtheria 2 5.00 Adhesions 2 5.00 Infection 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We have demonstrated that the ability of ANTXR2 to bind PA proteins with mutations at the D683 site maps to the receptor surface region containing residues G153 and L154 that engage PA domain 2.

domain 2 Binding (engage) of

1) Confidence 0.00 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1617126 Disease Relevance 0.28 Pain Relevance 0

The differential ability of ANTXR1 and ANTXR2 to bind D683 mutant PA proteins was mapped to nonconserved receptor residues at the binding interface with PA domain 2.

domain 2 Binding (binding) of

2) Confidence 0.00 Published 2006 Journal PLoS Pathogens Section Abstract Doc Link PMC1617126 Disease Relevance 0.68 Pain Relevance 0

General Comments

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