INT198659

Context Info Confidence 0.01 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.51 Pain Relevance 0.22

peptidase activity (F10) extracellular region (F10) plasma membrane (F10)

Anatomy Link Frequency endothelial cell 1 F10 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 142 94.36 cytokine 149 79.48 Inflammatory response 10 5.00 corticosteroid 2 5.00 depression 2 5.00 addiction 2 5.00 Central nervous system 1 5.00 Inflammatory marker 1 5.00 Inflammatory mediators 1 5.00 monoamine 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 154 94.36 Malaria 210 72.36 Infection 23 67.88 Adhesions 12 61.60 Disease 97 50.00 Sepsis 75 5.00 Coma 33 5.00 Acid Base Imbalance 28 5.00 Encephalopathy 27 5.00 Cerebral Malaria 24 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

When bound to thrombomodulin, a thrombin receptor on the endothelial cell surface, thrombin activates protein C, which can degrade Factor VIIIa and Factor Va, essential cofactors in the activation of Factor X and prothrombin respectively [164].

Protein_catabolism (degrade) of Factor X in endothelial cell

1) Confidence 0.01 Published 2006 Journal Malar J Section Body Doc Link PMC1629020 Disease Relevance 0.51 Pain Relevance 0.22

General Comments

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