INT198787

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Context Info
Confidence 0.73
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.56
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Cyb5d2) molecular_function (Cyb5d2) cellular_component (Cyb5d2)
biological_process (Cyb5d2)
Anatomy Link Frequency
microglial cell 1
Cyb5d2 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 3 62.40 Quite High
Inflammation 33 25.40 Quite Low
imagery 12 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
antiepileptic Drug 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 9 99.64 Very High Very High Very High
Disease 137 98.16 Very High Very High Very High
Neurodegenerative Disease 9 61.04 Quite High
Lipidosis 7 57.68 Quite High
Pick Disease Of The Brain 12 50.00 Quite Low
Mucopolysaccharidoses 3 50.00 Quite Low
Contagious Ecthyma 3 49.60 Quite Low
Gangliosidoses 2 36.64 Quite Low
Aging 3 25.80 Quite Low
INFLAMMATION 30 25.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To make a “clipped” version of Tol2 transposon, S2EF1a-GM2 expression cassette was amplified from pDB371 [13] using primers Tol2-sph-F (5?
Localization (cassette) of GM2
1) Confidence 0.73 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1635535 Disease Relevance 0 Pain Relevance 0
Other stimuli that could trigger microglial cell priming, like cell vacuolation and death and/or secondary accumulation of GM2 and GM3 gangliosides [35], were absent at this stage.
Localization (accumulation) of GM2 in microglial cell associated with death
2) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396504 Disease Relevance 0.22 Pain Relevance 0.03
Yet, the increase of GM2 occurs much earlier and is more prominent in NP-C than in other lysosomal diseases [63].
Localization (increase) of GM2 associated with disease
3) Confidence 0.10 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2902432 Disease Relevance 0.34 Pain Relevance 0

General Comments

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