INT198787

Context Info Confidence 0.73 First Reported 2006 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 0.56 Pain Relevance 0.03

extracellular region (Cyb5d2) molecular_function (Cyb5d2) cellular_component (Cyb5d2) biological_process (Cyb5d2)

Anatomy Link Frequency microglial cell 1 Cyb5d2 (Mus musculus)

Pain Link Frequency Relevance Heat chemokine 3 62.40 Inflammation 33 25.40 imagery 12 5.00 Central nervous system 3 5.00 ketamine 2 5.00 cytokine 2 5.00 cINOD 2 5.00 cerebral cortex 1 5.00 anesthesia 1 5.00 antiepileptic Drug 1 5.00

Disease Link Frequency Relevance Heat Death 9 99.64 Disease 137 98.16 Neurodegenerative Disease 9 61.04 Lipidosis 7 57.68 Pick Disease Of The Brain 12 50.00 Mucopolysaccharidoses 3 50.00 Contagious Ecthyma 3 49.60 Gangliosidoses 2 36.64 Aging 3 25.80 INFLAMMATION 30 25.40

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

To make a “clipped” version of Tol2 transposon, S2EF1a-GM2 expression cassette was amplified from pDB371 [13] using primers Tol2-sph-F (5?

Localization (cassette) of GM2

1) Confidence 0.73 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1635535 Disease Relevance 0 Pain Relevance 0

Other stimuli that could trigger microglial cell priming, like cell vacuolation and death and/or secondary accumulation of GM2 and GM3 gangliosides [35], were absent at this stage.

Localization (accumulation) of GM2 in microglial cell associated with death

2) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396504 Disease Relevance 0.22 Pain Relevance 0.03

Yet, the increase of GM2 occurs much earlier and is more prominent in NP-C than in other lysosomal diseases [63].

Localization (increase) of GM2 associated with disease

3) Confidence 0.10 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2902432 Disease Relevance 0.34 Pain Relevance 0

General Comments

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