INT198852

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Context Info
Confidence 0.61
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 8.00
Pain Relevance 1.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Ucp1) mitochondrion (Ucp1) transmembrane transport (Ucp1)
Anatomy Link Frequency
BAT 3
brown fat 1
brain 1
skeletal muscle 1
chest 1
Ucp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Angina 67 100.00 Very High Very High Very High
Inflammation 23 91.28 High High
agonist 23 90.48 High High
Pain 29 87.84 High High
Inflammatory response 1 85.28 High High
Lasting pain 6 83.52 Quite High
cINOD 1 60.04 Quite High
Eae 35 5.00 Very Low Very Low Very Low
tolerance 16 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 602 100.00 Very High Very High Very High
Angina 67 100.00 Very High Very High Very High
Prolapse 56 100.00 Very High Very High Very High
Hypoxia 3 99.92 Very High Very High Very High
Death 14 99.38 Very High Very High Very High
Targeted Disruption 206 98.64 Very High Very High Very High
Metabolic Syndrome 13 92.60 High High
Dyslipidemia /

Combined Dyslipidemia

2 91.36 High High
INFLAMMATION 30 91.28 High High
Pain 35 87.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Noteworthy, DBKO mice simultaneously lacking the ob and iNOS genes showed a statistically significant increase in Ucp-1 (p<0.05) and Ucp-3 (p<0.05) transcripts and proteins compared to ob/ob mice.
Positive_regulation (increase) of Ucp-1 associated with targeted disruption and obesity
1) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881035 Disease Relevance 1.42 Pain Relevance 0
The outcome of UCP is highly dependent on the speed and appropriateness of the intervention offered.3 The risks to the mother often arise as a result of problems associated with the kind of intervention, such as cesarean section, used to rescue the baby.4 There is, however, an increase risk of fetal brain damage or death arising from acute hypoxia in cases of UCP, with a perinatal mortality rate of 9% to 49%.5,6 Having said that, the perinatal mortality rate associated with cord presentation is however slightly lower than in UCP.2,7
Positive_regulation (cases) of UCP in brain associated with hypoxia, prolapse and death
2) Confidence 0.43 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971738 Disease Relevance 1.01 Pain Relevance 0
3-adrenergic receptors, leading to the activation of the BAT-specific uncoupling protein-1 (Ucp-1).
Positive_regulation (activation) of BAT-specific uncoupling protein-1 in BAT associated with obesity
3) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881035 Disease Relevance 0.73 Pain Relevance 0
Accordingly, mitochondrial uncoupling proteins 1 and 3 (Ucp-1 and Ucp-3) were upregulated in brown adipose tissue (BAT) of DBKO mice as compared to ob/ob rodents.


Positive_regulation (upregulated) of Ucp-1 in BAT associated with targeted disruption and obesity
4) Confidence 0.41 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2881035 Disease Relevance 1.32 Pain Relevance 0
3-adrenergic receptors, leading to the activation of the BAT-specific uncoupling protein-1 (Ucp-1).
Positive_regulation (activation) of Ucp-1 in BAT associated with obesity
5) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881035 Disease Relevance 0.73 Pain Relevance 0
, allowing the activation of Ucp-1 and other brown fat-specific genes [10], [11].
Positive_regulation (activation) of Ucp-1 in brown fat
6) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881035 Disease Relevance 0.61 Pain Relevance 0
The unexplained chest pain (UCP) is often experienced for more than three months as was shown in two qualitative studies [4,5] that included 20 subject each.
Positive_regulation (experienced) of UCP in chest associated with angina
7) Confidence 0.32 Published 2006 Journal BMC Nurs Section Body Doc Link PMC1635695 Disease Relevance 1.49 Pain Relevance 1.30
activators induce UCP1 in brown adipose tissue, UCP2 in liver, and UCP3 in skeletal muscle [14–16].
Positive_regulation (induce) of UCP1 in skeletal muscle associated with obesity
8) Confidence 0.24 Published 2010 Journal PPAR Research Section Body Doc Link PMC2929615 Disease Relevance 0.60 Pain Relevance 0.23

General Comments

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