INT198873

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Context Info
Confidence 0.35
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.45
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Lrp1) endosome (Lrp1) plasma membrane (Lrp1)
nucleus (Lrp1) cytoplasm (Lrp1)
Anatomy Link Frequency
liver 1
Lrp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 7 80.24 Quite High
Inflammation 32 79.92 Quite High
Thalamus 9 70.88 Quite High
cytokine 8 69.60 Quite High
Inflammatory response 2 56.96 Quite High
long-term potentiation 20 15.44 Low Low
Hippocampus 20 5.00 Very Low Very Low Very Low
metalloproteinase 9 5.00 Very Low Very Low Very Low
nMDA receptor 5 5.00 Very Low Very Low Very Low
cINOD 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 211 89.76 High High
Alzheimer's Dementia 191 89.52 High High
Disease 202 85.84 High High
Disorder Of Lipid Metabolism 10 84.48 Quite High
Drug Induced Neurotoxicity 5 82.56 Quite High
INFLAMMATION 36 79.92 Quite High
Vascular Disease 16 67.28 Quite High
Toxicity 9 57.08 Quite High
Pathologic Processes 1 53.24 Quite High
Adhesions 7 50.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the recent observation that full length LRP1 levels were unaltered in BACE1-/- mice, compared to wild type mice has shed doubt as to whether LRP is a true physiological substrate of BACE1 [126].
Regulation (unaltered) of LRP1
1) Confidence 0.35 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.53 Pain Relevance 0.18
LRP alters APP trafficking and processing
Regulation (alters) of LRP
2) Confidence 0.28 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0.42 Pain Relevance 0
deposition by other proteins involved in cholesterol metabolism: liver X receptor, LRP and ABCA1
Regulation (deposition) of LRP in liver
3) Confidence 0.22 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.49 Pain Relevance 0.06

General Comments

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