INT198900

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Context Info
Confidence 0.26
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.44
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Vldlr) extracellular space (Vldlr) nucleus (Vldlr)
lipid metabolic process (Vldlr)
Anatomy Link Frequency
plasma 1
Vldlr (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 8 91.32 High High
agonist 3 25.36 Quite Low
long-term potentiation 12 5.00 Very Low Very Low Very Low
Bile 7 5.00 Very Low Very Low Very Low
nMDA receptor 5 5.00 Very Low Very Low Very Low
tolerance 5 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 38 100.00 Very High Very High Very High
Hyperlipoproteinemia Type Ii 66 95.12 Very High Very High Very High
Coagulation Disorder 6 92.88 High High
Atherosclerosis 43 90.48 High High
Fetal Nutrition Disorders 1 63.24 Quite High
Hyperlipidemia 23 52.44 Quite High
Pressure And Volume Under Development 29 50.00 Quite Low
Targeted Disruption 28 48.40 Quite Low
Disease 48 45.04 Quite Low
Cancer 7 23.64 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ApoER2 and VLDLR proteolytic events are also increased by extracellular ligand binding [148].
Positive_regulation (increased) of VLDLR
1) Confidence 0.26 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0 Pain Relevance 0.12
In addition to the LDLR gene augmentation approach, the successful use of the VLDLR as an effective surrogate lipoprotein receptor gene [139-141,153,216,217] for the complementation of mutated LDLR function in homozygote FH patients would also open an alternative therapeutic avenue, since it would avoid the immune problem in patients with no natural LDLR.
Positive_regulation (effective) of VLDLR associated with hyperlipoproteinemia type ii
2) Confidence 0.17 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0.48 Pain Relevance 0
Moreover, the analysis of plasma HDL-cholesterol concentration showed a similar increase for animals of the C-OB and LP-OB group indicating that the higher values of total cholesterol observed in LP-OB mice were due to increased amount of LDL- and VLDL-cholesterol.
Positive_regulation (increase) of VLDL-cholesterol in plasma associated with disorder of lipid metabolism
3) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2936567 Disease Relevance 0.96 Pain Relevance 0

General Comments

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