INT19903

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Context Info
Confidence 0.57
First Reported 1982
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 2.80
Pain Relevance 3.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Cux1) nucleus (Cux1) protein binding, bridging (Cux1)
DNA binding (Cux1) cytoplasm (Cux1)
Cux1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Endogenous opioid 3 99.48 Very High Very High Very High
tetrodotoxin 12 99.28 Very High Very High Very High
c fibre 6 99.06 Very High Very High Very High
ischemia 15 95.72 Very High Very High Very High
Morphine 3 90.92 High High
fluoxetine 11 90.12 High High
Desipramine 6 89.64 High High
Intracerebroventricular 9 88.16 High High
antidepressant 83 86.04 High High
Action potential 1 83.96 Quite High
Disease Link Frequency Relevance Heat
Coronary Artery Disease 9 95.72 Very High Very High Very High
Death 6 94.04 High High
Pressure And Volume Under Development 6 89.52 High High
Heart Rate Under Development 15 88.16 High High
Arrhythmias 2 Under Development 15 87.84 High High
Reperfusion Injury 9 75.00 Quite High
Cv Unclassified Under Development 6 66.44 Quite High
Toxicity 1 61.44 Quite High
Coronary Heart Disease 3 59.84 Quite High
Depression 19 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BCCE (0.5--10 micrograms ICV) produced a dose-dependent reduction in the anticonflict activity of CDP.
Negative_regulation (reduction) of CDP
1) Confidence 0.57 Published 1982 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 6296901 Disease Relevance 0 Pain Relevance 0.06
The protective effect of CDP-choline is not related to its pressor effect.
Negative_regulation (effect) of CDP-choline
2) Confidence 0.43 Published 2008 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 18504556 Disease Relevance 0.80 Pain Relevance 0.16
Activation of central muscarinic receptors and vagal pathways mediates the protective effect of CDP-choline.
Negative_regulation (effect) of CDP-choline
3) Confidence 0.37 Published 2008 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 18504556 Disease Relevance 0.81 Pain Relevance 0.16
If CDP potentiates endogenous opioid release, then NLX should block the CDP effect.
Negative_regulation (block) of CDP associated with endogenous opioid
4) Confidence 0.37 Published 1990 Journal Behav. Neurosci. Section Abstract Doc Link 2107826 Disease Relevance 0 Pain Relevance 0.81
Bilateral vagotomy completely abolished the protective effect of CDP-choline in the reperfusion period.
Negative_regulation (effect) of CDP-choline
5) Confidence 0.37 Published 2008 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 18504556 Disease Relevance 1.12 Pain Relevance 0.26
Increasing concentrations of neomycin produced complete blockade of both CDP-DG and PI responses.
Negative_regulation (blockade) of CDP
6) Confidence 0.30 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0.06 Pain Relevance 0.38
In contrast, CDPs elicited by C-fibre stimulation persisted with longer latency and reduced amplitude in the first part of the CDP.
Negative_regulation (reduced) of CDP associated with c fibre
7) Confidence 0.17 Published 2001 Journal Neurosci. Res. Section Abstract Doc Link 11274740 Disease Relevance 0 Pain Relevance 1.51

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