INT199099

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Context Info
Confidence 0.12
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.40
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Decr1) oxidoreductase activity (Decr1) nucleus (Decr1)
cytoplasm (Decr1)
Anatomy Link Frequency
plasma 1
Neuronal 1
microglia 1
Decr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 1 99.02 Very High Very High Very High
Dopamine 11 98.56 Very High Very High Very High
ischemia 2 98.02 Very High Very High Very High
Central nervous system 2 97.92 Very High Very High Very High
imagery 7 91.52 High High
Dorsal horn 13 91.04 High High
Inflammation 17 88.08 High High
Substantia nigra 17 79.76 Quite High
Spinal cord 7 79.16 Quite High
Hippocampus 14 61.00 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 3 98.60 Very High Very High Very High
Hypertrophy 1 98.16 Very High Very High Very High
Cv Unclassified Under Development 2 98.02 Very High Very High Very High
Diabetes Mellitus 26 97.68 Very High Very High Very High
Drug Induced Neurotoxicity 12 94.80 High High
Parkinson's Disease 89 94.24 High High
Pathologic Processes 1 93.56 High High
INFLAMMATION 26 88.08 High High
Death 18 78.64 Quite High
Infection 13 65.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Also, NADPH oxidase in activated microglia is a source of O2•?
Localization (oxidase) of NADPH in microglia
1) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747267 Disease Relevance 0.46 Pain Relevance 0.20
Age-related increased superoxide production in brain in vivo is attenuated by inhibition of NADPH oxidase or by treatment with a superoxide dismutase mimetic, and is emulated by increased levels of plasma IL-6
Localization (oxidase) of NADPH in plasma
2) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.05 Pain Relevance 0.07
Neuronal cells respond to toxic insults including ischemia [73], zinc overload [72], and nerve growth factor deprivation [71] by inducing the expression and translocation of NADPH oxidase subunits.
Localization (translocation) of NADPH in Neuronal associated with nerve growth factor and ischemia
3) Confidence 0.06 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.38 Pain Relevance 0.15
NADPH oxidase is composed of mainly four subunits, two of them are localized in the membrane (gp91phox and p22phox) and the others are in the cytosol (p47phox, p67phox) [29].
Localization (localized) of NADPH
4) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954163 Disease Relevance 0.80 Pain Relevance 0.04
The decrease of both AP and NADPH-d labeling was most profound in the medial portion of lamina I and II.
Localization (decrease) of NADPH-d
5) Confidence 0.05 Published 2007 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC1865541 Disease Relevance 0.71 Pain Relevance 0.15

General Comments

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