INT199109

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Context Info
Confidence 0.02
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 2.73
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Akt1, Arhgdia) transport (Akt1) aging (Akt1)
enzyme binding (Akt1) carbohydrate metabolic process (Akt1) cytosol (Akt1)
Anatomy Link Frequency
plasma 2
monocytes 2
microglia 2
Akt1 (Mus musculus)
Arhgdia (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory stimuli 16 99.96 Very High Very High Very High
Inflammation 80 97.16 Very High Very High Very High
Kinase C 8 59.40 Quite High
cINOD 48 5.00 Very Low Very Low Very Low
cytokine 40 5.00 Very Low Very Low Very Low
Inflammatory response 40 5.00 Very Low Very Low Very Low
chemokine 16 5.00 Very Low Very Low Very Low
Central nervous system 8 5.00 Very Low Very Low Very Low
Nerve growth factor 8 5.00 Very Low Very Low Very Low
ischemia 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 152 99.78 Very High Very High Very High
Disease 464 69.44 Quite High
Hyperlipidemia 8 65.12 Quite High
Stress 24 50.00 Quite Low
Aging 8 38.00 Quite Low
Cognitive Disorder 48 35.80 Quite Low
Death 64 5.00 Very Low Very Low Very Low
Amyloid Plaque 56 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 48 5.00 Very Low Very Low Very Low
Drug Induced Neurotoxicity 40 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In resting cells, Rac is anchored in the cytosol through an interaction between its C-terminal prenyl moiety and the GDP dissociation inhibitor, RhoGDI.
Rac Binding (interaction) of RhoGDI
1) Confidence 0.02 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.10 Pain Relevance 0.08
During activation by an inflammatory stimulus, Rac binds GTP and dissociates from RhoGDI.
Rac Binding (binds) of RhoGDI associated with inflammatory stimuli
2) Confidence 0.02 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.10 Pain Relevance 0.08
The protein isoprenylation of Rac is critical for Rac's subcellular localization, interactions with RhoGDI, anchoring to the plasma membrane and ultimately to the activation of inflammatory signaling pathways [114].
Rac Binding (interactions) of RhoGDI in plasma associated with inflammation
3) Confidence 0.02 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.47 Pain Relevance 0.14
In addition, treatment of monocytes and microglia with simvastatin has been shown to uncouple the interaction between Rac and its negative regulator Rho-GDI and also disrupts Rac's ability to interact with the plasma membrane [116].
Rac Binding (interaction) of Rho-GDI in monocytes
4) Confidence 0.02 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.40 Pain Relevance 0.11
The protein isoprenylation of Rac is critical for Rac's subcellular localization, interactions with RhoGDI, anchoring to the plasma membrane and ultimately to the activation of inflammatory signaling pathways [114].
Rac Binding (interactions) of RhoGDI in plasma associated with inflammation
5) Confidence 0.02 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.46 Pain Relevance 0.14
In addition, treatment of monocytes and microglia with simvastatin has been shown to uncouple the interaction between Rac and its negative regulator Rho-GDI and also disrupts Rac's ability to interact with the plasma membrane [116].
Rac Binding (interaction) of Rho-GDI in monocytes
6) Confidence 0.02 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.40 Pain Relevance 0.11
In addition, treatment of monocytes and microglia with simvastatin has been shown to uncouple the interaction between Rac and its negative regulator Rho-GDI and also disrupts Rac's ability to interact with the plasma membrane [116].
Rac Binding (interaction) of Rho-GDI in microglia
7) Confidence 0.01 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.40 Pain Relevance 0.11
In addition, treatment of monocytes and microglia with simvastatin has been shown to uncouple the interaction between Rac and its negative regulator Rho-GDI and also disrupts Rac's ability to interact with the plasma membrane [116].
Rac Binding (interaction) of Rho-GDI in microglia
8) Confidence 0.01 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.40 Pain Relevance 0.11

General Comments

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