INT199138

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Context Info
Confidence 0.78
First Reported 2000
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 7
Disease Relevance 4.07
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (MT3) intracellular (MT3)
Anatomy Link Frequency
bladder 4
MT-3 3
MT3 (Homo sapiens)
Pain Link Frequency Relevance Heat
interstitial cystitis 7 97.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Carcinoma In Situ 21 99.84 Very High Very High Very High
Cancer 7 99.00 Very High Very High Very High
Bladder Cancer 63 98.44 Very High Very High Very High
Interstitial Cystitis 7 97.16 Very High Very High Very High
Bladder Disease 7 96.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The goal of the present study was to determine if the expression of metallothionein isoform 3 (MT-3) might serve as a biomarker for human bladder cancer.
Gene_expression (expression) of MT-3 in bladder associated with bladder cancer
1) Confidence 0.78 Published 2000 Journal Environ Health Perspect Section Abstract Doc Link PMC1638035 Disease Relevance 0.25 Pain Relevance 0
Immunohistochemical analysis demonstrated that MT-3 was expressed in carcinoma in situ (CIS), high-grade bladder cancer, low-grade bladder cancer, and dysplastic lesions.
Gene_expression (expressed) of MT-3 in bladder associated with bladder cancer and carcinoma in situ
2) Confidence 0.78 Published 2000 Journal Environ Health Perspect Section Abstract Doc Link PMC1638035 Disease Relevance 1.04 Pain Relevance 0.10
To accomplish this goal, we defined the localization and expression of MT-3 protein and mRNA using fresh and archival biopsy specimens obtained from patients undergoing differential diagnosis for a variety of bladder disorders.
Gene_expression (expression) of MT-3 protein in MT-3 associated with bladder disease
3) Confidence 0.78 Published 2000 Journal Environ Health Perspect Section Abstract Doc Link PMC1638035 Disease Relevance 0.27 Pain Relevance 0
The absence of MT-3 expression in the normal bladder was further confirmed by demonstrating that MT-3 mRNA could not be detected using reverse transcriptase-polymerase chain reaction (RT-PCR) or MT-3 protein using immunoblot.
Gene_expression (expression) of MT-3 in MT-3
4) Confidence 0.78 Published 2000 Journal Environ Health Perspect Section Abstract Doc Link PMC1638035 Disease Relevance 0.69 Pain Relevance 0.08
The goal of the present study was to determine if the expression of metallothionein isoform 3 (MT-3) might serve as a biomarker for human bladder cancer.
Gene_expression (expression) of metallothionein isoform 3 in bladder associated with bladder cancer
5) Confidence 0.78 Published 2000 Journal Environ Health Perspect Section Abstract Doc Link PMC1638035 Disease Relevance 0.25 Pain Relevance 0
We used immunohistochemistry, immunoblot, and RT-PCR analysis to define the localization and expression of MT-3 protein and mRNA.
Gene_expression (expression) of MT-3 protein in MT-3
6) Confidence 0.67 Published 2000 Journal Environ Health Perspect Section Abstract Doc Link PMC1638035 Disease Relevance 0.54 Pain Relevance 0.06
The finding that MT-3 expression is minimal in normal bladder suggests that MT-3 might be developed into an effective biomarker for bladder cancer.
Gene_expression (expression) of MT-3 in bladder associated with bladder cancer
7) Confidence 0.60 Published 2000 Journal Environ Health Perspect Section Abstract Doc Link PMC1638035 Disease Relevance 1.04 Pain Relevance 0.07

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