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Context Info
Confidence 0.57
First Reported 2006
Last Reported 2008
Negated 2
Speculated 0
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 18.97
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SAMSN1) nucleus (SAMSN1) cytoplasm (SAMSN1)
Anatomy Link Frequency
hepatocytes 2
liver 2
SAMSN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 296 98.64 Very High Very High Very High
Paracetamol 12 96.28 Very High Very High Very High
alcohol 115 95.72 Very High Very High Very High
Inflammation 146 93.84 High High
Inflammatory response 22 78.92 Quite High
cytokine 42 55.20 Quite High
Bile 12 14.80 Low Low
chemokine 12 5.00 Very Low Very Low Very Low
Pain 11 5.00 Very Low Very Low Very Low
COX2 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nash(non-alcoholic Steatohepatitis) 1061 100.00 Very High Very High Very High
Alcoholic Liver Diseases 95 100.00 Very High Very High Very High
Fatty Liver 356 99.98 Very High Very High Very High
Hepatitis 233 99.64 Very High Very High Very High
Fibrosis 322 98.64 Very High Very High Very High
Cirrhosis 161 98.48 Very High Very High Very High
Hepatitis Virus Infection 15 98.20 Very High Very High Very High
Liver Disease 215 97.86 Very High Very High Very High
Disorder Of Lipid Metabolism 55 97.56 Very High Very High Very High
Stress 250 96.34 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However the NAS was intended for use in monitoring changes in liver disease and other clinical situations, and was not intended to replace the pathologist's determination of whether NASH is present or not.
Neg (not) Gene_expression (present) of NASH in liver associated with liver disease and nash(non-alcoholic steatohepatitis)
1) Confidence 0.57 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1657015 Disease Relevance 1.01 Pain Relevance 0.03
In the training group, there was a clinically significant discordance in three patients (2%), all with NT predicting NASH and biopsy showing no NASH.
Gene_expression (biopsy) of NASH associated with nash(non-alcoholic steatohepatitis)
2) Confidence 0.55 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1657015 Disease Relevance 1.28 Pain Relevance 0
Sensitivity analyses revealed that the NT AUROCs for the diagnosis of NASH (Table 6) and the diagnosis of borderline NASH or NASH (Table 7) were not affected by groups, ALT values, alcohol consumption, Gilbert's syndrome, acute inflammation, absence of steatosis, or biopsy sample length.
Gene_expression (diagnosis) of NASH associated with nash(non-alcoholic steatohepatitis), inflammation, syndrome and alcohol
3) Confidence 0.55 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1657015 Disease Relevance 1.34 Pain Relevance 0.09
Unfortunately, many patients with NAFLD or NASH have normal ALT levels and some of them have advanced liver fibrosis [46-48].
Gene_expression (have) of NASH in liver associated with fatty liver, fibrosis, nash(non-alcoholic steatohepatitis) and cirrhosis
4) Confidence 0.55 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1657015 Disease Relevance 1.15 Pain Relevance 0.19
Indeed the value of NT for this diagnostic of NASH was fair (AUROC = 0.80 in the validation group).
Gene_expression (value) of NASH associated with nash(non-alcoholic steatohepatitis)
5) Confidence 0.55 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1657015 Disease Relevance 0.88 Pain Relevance 0
Cases with NAS of 0 to 2 were considered not diagnostic of NASH; on the other hand, cases with scores of 5 or greater were diagnosed as NASH.
Gene_expression (diagnosed) of NASH associated with nash(non-alcoholic steatohepatitis)
6) Confidence 0.55 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1657015 Disease Relevance 1.39 Pain Relevance 0.31
In the training group, there was a clinically significant discordance in three patients (2%), all with NT predicting NASH and biopsy showing no NASH.
Gene_expression (biopsy) of NASH associated with nash(non-alcoholic steatohepatitis)
7) Confidence 0.55 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1657015 Disease Relevance 1.28 Pain Relevance 0
In our NASH population there was a much lower prevalence of cirrhosis, as well as severe steato-hepatitis in comparison with the population of ASH [36].
Gene_expression (population) of NASH associated with nash(non-alcoholic steatohepatitis), cirrhosis and hepatitis
8) Confidence 0.55 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1657015 Disease Relevance 1.95 Pain Relevance 0.03
ROC curves of NT for predicting NASH or borderline NASH are illustrated in Figures 1 to 3.
Gene_expression (predicting) of NASH associated with nash(non-alcoholic steatohepatitis)
9) Confidence 0.55 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1657015 Disease Relevance 1.29 Pain Relevance 0.06
ROC curves of NT for predicting NASH or borderline NASH are illustrated in Figures 1 to 3.
Gene_expression (predicting) of NASH associated with nash(non-alcoholic steatohepatitis)
10) Confidence 0.55 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1657015 Disease Relevance 1.30 Pain Relevance 0.06
The second endpoint was the determination of the pathologist of whether the NASH is present or not.


Neg (not) Gene_expression (present) of NASH associated with nash(non-alcoholic steatohepatitis)
11) Confidence 0.49 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1657015 Disease Relevance 1.36 Pain Relevance 0.29
High levels of intracellular oxidative stress may also be reached within hepatocytes damaged by specific toxins (for example, CCl4 and acetaminophen) or aetiologies (for example, high levels of transition metal ions) or because of individual differences, including induction of peculiar cytochrome P450 isoforms (such as CYP2E1 in ASH/ALD or NASH), antioxidant status or even genetic polymorphisms.
Gene_expression (/) of NASH in hepatocytes associated with stress, nash(non-alcoholic steatohepatitis), paracetamol and alcoholic liver diseases
12) Confidence 0.04 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 1.49 Pain Relevance 0.24
This suggests that the presence of oxidative stress-triggered immune reactions could be an independent predictor of NAFLD progression to an advanced stage of fibrosis and then, likely, as a mechanism potentially contributing to NAFLD progression to NASH.
Gene_expression (progression) of NASH associated with fatty liver, stress, fibrosis and nash(non-alcoholic steatohepatitis)
13) Confidence 0.04 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 1.61 Pain Relevance 0.25
The disappearance of the keratin immunostaining in ballooned hepatocytes is reasonably specific for ASH and NASH, since it is not seen in ballooned cells of viral hepatitis or toxic damage and can therefore be used as an objective morphologic parameter in grading of steatohepatitis (Lackner et al. 2008).
Gene_expression (specific) of NASH in hepatocytes associated with nash(non-alcoholic steatohepatitis) and hepatitis virus infection
14) Confidence 0.01 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.73 Pain Relevance 0.08
MDBs are typical morphological features of ASH and NASH, although NASH usually exhibits slightly less prominent MDBs than the ones seen in ASH (Brunt 2004; Zatloukal et al. 2007).
Gene_expression (features) of NASH associated with nash(non-alcoholic steatohepatitis)
15) Confidence 0.01 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.88 Pain Relevance 0

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