INT19948

Context Info Confidence 0.63 First Reported 1988 Last Reported 2010 Negated 1 Speculated 2 Reported most in Abstract Documents 34 Total Number 43 Disease Relevance 14.69 Pain Relevance 15.44

mitochondrion (Sds) lyase activity (Sds) cellular_component (Sds) cellular amino acid metabolic process (Sds) cytoplasm (Sds)

Anatomy Link Frequency neurons 10 spinal cord 2 SDH 2 synapses 2 postsynaptic membrane 1 Sds (Rattus norvegicus)

Pain Link Frequency Relevance Heat Dorsal horn 1234 100.00 spinal dorsal horn 59 100.00 depression 22 100.00 palliative 12 100.00 Paracetamol 5 99.98 Spinal cord 241 99.84 Spinal nerve ligature 228 99.82 ASIC 5 99.82 dorsal root ganglion 14 99.80 Action potential 202 99.54

Disease Link Frequency Relevance Heat Depression 39 100.00 Nervous System Injury 1076 99.72 Neuropathic Pain 521 99.72 Fever 2 99.34 Ganglion Cysts 15 99.32 Pain 130 99.18 Irritable Bowel Syndrome / Irritable Bowel Syndrome Super / Visceral Pain 8 99.16 Nociception 97 96.96 Inflammatory Pain 4 96.00 Febrile Convulsions 5 95.72

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

WDR and HT neurons were recorded in both the SDH and DDH, including nucleus proprius, an area not typically associated with nociceptive transmission at other levels of the cord.

Gene_expression (recorded) of SDH in neurons associated with nociception

1) Confidence 0.63 Published 1994 Journal J. Neurophysiol. Section Abstract Doc Link 8201437 Disease Relevance 0.10 Pain Relevance 0.11

Neural circuitry of the spinal superficial dorsal horn (SDH) (laminae I and II) and its relationship to pain and other somatosensory phenomena remain poorly understood.

Gene_expression (circuitry) of SDH in SDH associated with pain and dorsal horn

2) Confidence 0.59 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15829642 Disease Relevance 0.10 Pain Relevance 0.35

The statistical evaluation presents that mean SDS (self-rating depression score) certifies the presence of signs of mildly depression among palliative care female patients (SDS range was 50-59).

Gene_expression (range) of SDS associated with depression and palliative

3) Confidence 0.58 Published 2009 Journal Neoplasma Section Abstract Doc Link 19309220 Disease Relevance 1.36 Pain Relevance 0.82

The statistical evaluation presents that mean SDS (self-rating depression score) certifies the presence of signs of mildly depression among palliative care female patients (SDS range was 50-59).

Gene_expression (range) of SDS associated with depression and palliative

4) Confidence 0.58 Published 2009 Journal Neoplasma Section Abstract Doc Link 19309220 Disease Relevance 1.41 Pain Relevance 0.85

In transverse hippocampal CA1 slices from 104 rats, temperature increase from 34 degrees to 40 degrees C produced a series of spreading depressions (SDs), called hyperthermic SDs.

Gene_expression (produced) of SDs associated with depression and fever

5) Confidence 0.52 Published 2000 Journal J. Neurophysiol. Section Abstract Doc Link 10980008 Disease Relevance 1.29 Pain Relevance 0.03

Both doses of acetaminophen produced significant elevations of serum alanine aminotransferase (ALT) and sorbitol dehydrogenase (SDH) activities in 4-month-old rats.

Gene_expression (produced) of SDH associated with paracetamol

6) Confidence 0.50 Published 1988 Journal Drug Chem Toxicol Section Abstract Doc Link 3181038 Disease Relevance 0.24 Pain Relevance 0.42

However, the cellular distribution and the functional consequence of increased ASIC subunit expression in the SDH remain unclear.

Gene_expression (expression) of SDH in SDH associated with spinal dorsal horn and asic

7) Confidence 0.37 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17928456 Disease Relevance 0.61 Pain Relevance 0.99

There were evidences that the levels of SDH, SOD, GSH, AST, ALT were significantly increased by a taurine supplement in serum, and the level of MDA decreased [32-35].

Gene_expression (levels) of SDH

8) Confidence 0.36 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994374 Disease Relevance 0.05 Pain Relevance 0

-alanine supplement in adult rats, the levels of AKP, LDH, SDH and GSH were obviously reduced, and the levels of SOD, NOS and NO had no changes.

Gene_expression (levels) of SDH

9) Confidence 0.36 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994374 Disease Relevance 0 Pain Relevance 0

As shown in Fig.4, the levels of SOD, ACP, SDH, NOS and NO were obviously increased by taurine administration in adult rats, the levels of AKP, AST and ALT were significantly decreased, but the levels of MDA, LDH and GSH had no changes.

Gene_expression (levels) of SDH

10) Confidence 0.36 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994374 Disease Relevance 0 Pain Relevance 0

RESULTS: Mean scores and SDs for individual items were low.

Gene_expression (scores) of SDs

11) Confidence 0.32 Published 2010 Journal Cancer Nurs Section Body Doc Link 20357656 Disease Relevance 0.08 Pain Relevance 0

The levels of SOD, ACP, LDH, SDH, NOS, NO and GSH were significantly elevated by taurine administration in aged rats, the levels of AST and ALT were significantly decreased, but the levels of AKP and MDA had no changes.

Gene_expression (levels) of SDH

12) Confidence 0.31 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994374 Disease Relevance 0 Pain Relevance 0

affected repetitive AP discharge in neonatal SDH neurons, we examined the firing frequency during prolonged current injections in a subset of SDH neurons which exhibited a tonic pattern of firing (see Figure 6A).

Gene_expression (neurons) of SDH in neurons associated with action potential and dorsal horn

13) Confidence 0.29 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657778 Disease Relevance 1.13 Pain Relevance 0.46

in SDH neurons following SNI (Figure 4B) appears to result from a downregulation in NMDAR function (Figure 4C).

Gene_expression (neurons) of SDH in neurons associated with nervous system injury and dorsal horn

14) Confidence 0.29 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657778 Disease Relevance 0.53 Pain Relevance 0.49

Thus, an increase in TNFR1 expression in SDH neurons under neuropathic conditions could increase the number of functional synapses via AMPAR insertion into the postsynaptic membrane and thus potentiate glutamatergic signaling.

Gene_expression (expression) of SDH in postsynaptic membrane associated with neuropathic pain and dorsal horn

15) Confidence 0.29 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657778 Disease Relevance 0.10 Pain Relevance 0.26

In the thoracolumbar spinal segments, Fos was induced primarily in the SDH and the area around the central canal. (2) Injection of FG into the PBn produced dense retrograde labeling in the SDH, the lateral deeper gray matter and the area around the central canal at the lumbosacral and thoracolumbar levels. (3) In the lumbosacral spinal cord, 30-40% of the FG labeled cells double labeled for Fos.

Gene_expression (produced) of SDH in central canal associated with dorsal horn and spinal cord

16) Confidence 0.29 Published 2002 Journal Pain Section Abstract Doc Link 11790471 Disease Relevance 0.41 Pain Relevance 0.79

In the presence of SDS it dissociates, with loss of activity, into fragments of ca 30 and 10.5 kDa, but activity is regained when these fragments recombine in the absence of SDS.

Neg (absence) Gene_expression (absence) of SDS

17) Confidence 0.29 Published 1990 Journal FEBS Lett. Section Abstract Doc Link 2110531 Disease Relevance 0 Pain Relevance 0.18

The levels of SOD, ACP, LDH, SDH, NOS, NO and GSH were significantly elevated by taurine administration in aged rats, but the levels of AST and ALT were significantly decreased.

Gene_expression (levels) of SDH

18) Confidence 0.28 Published 2010 Journal J Biomed Sci Section Abstract Doc Link PMC2994374 Disease Relevance 0 Pain Relevance 0

To evaluate the effect of taurine on testis biochemical metabolism, the levels of ACP, AKP, LDH, SDH, AST, ALT, SOD, MDA, NOS and NO were detected in testes of adult and aged rats.

Gene_expression (levels) of SDH in testes

19) Confidence 0.28 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994374 Disease Relevance 0 Pain Relevance 0

The levels of SOD, ACP, SDH and NOS were obviously increased by taurine administration in adult rats, but the levels of AKP, AST, ALT and NO were significantly decreased.

Gene_expression (levels) of SDH

20) Confidence 0.28 Published 2010 Journal J Biomed Sci Section Abstract Doc Link PMC2994374 Disease Relevance 0 Pain Relevance 0

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