INT199644

Context Info Confidence 0.37 First Reported 2006 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 5 Disease Relevance 2.60 Pain Relevance 0.15

Anatomy Link Frequency cerebellar cortex 4 cerebral cortex 1 striatum 1 H2-Q10 (Mus musculus)

Pain Link Frequency Relevance Heat cerebral cortex 4 99.68 imagery 7 36.04 Pain 2 32.48 Sicca syndrome 6 20.68 tolerance 9 5.00 Inflammation 6 5.00 Spinal cord 5 5.00 withdrawal 3 5.00 ischemia 3 5.00 Paracetamol 3 5.00

Disease Link Frequency Relevance Heat Cerebellar Ataxia 48 99.76 Friedreich Ataxia 53 99.64 Hepatotoxicity 4 97.76 Syndrome 33 97.28 Stress 303 97.24 Ataxia 92 93.92 Frailty 9 92.16 Convulsion 2 84.32 Marinesco Sjogren Syndrome 6 83.56 Intellectual Impairment 5 81.84

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Preliminary data also demonstrate significant increases in Coenzyme Q9 and Q10 levels in the cerebral cortex, striatum, and cerebellar cortex of dwarf mice (Brown-Borg and Sharma, unpublished data).

Positive_regulation (increases) of Gene_expression (levels) of Q10 in cerebellar cortex associated with cerebral cortex

1) Confidence 0.37 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 0.24 Pain Relevance 0.05

Preliminary data also demonstrate significant increases in Coenzyme Q9 and Q10 levels in the cerebral cortex, striatum, and cerebellar cortex of dwarf mice (Brown-Borg and Sharma, unpublished data).

Positive_regulation (increases) of in striatum Gene_expression (levels) of Q10 in cerebellar cortex associated with cerebral cortex

2) Confidence 0.13 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 0.24 Pain Relevance 0.05

Preliminary data also demonstrate significant increases in Coenzyme Q9 and Q10 levels in the cerebral cortex, striatum, and cerebellar cortex of dwarf mice (Brown-Borg and Sharma, unpublished data).

Positive_regulation (increases) of in cerebral cortex Gene_expression (levels) of Q10 in cerebellar cortex associated with cerebral cortex

3) Confidence 0.13 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 0.24 Pain Relevance 0.05

Coenzyme Q10 deficiency with cerebellar ataxia

Positive_regulation (Coenzyme) of Gene_expression (deficiency) of Q10 associated with cerebellar ataxia

4) Confidence 0.05 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1664553 Disease Relevance 1.34 Pain Relevance 0

In addition, enhanced levels of H2CoQ10 and NADPH-CoQ reductase activity showed more resistant to oxidative stress than those of normal levels.

Positive_regulation (enhanced) of Gene_expression (levels) of H2CoQ10 associated with stress

5) Confidence 0.01 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275764 Disease Relevance 0.55 Pain Relevance 0

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