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Context Info
Confidence 0.04
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.96
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Cep290, Atf4) nucleus (Cep290, Atf4) cytoskeleton (Cep290, Atf4)
transport (Cep290) DNA binding (Atf4) cilium (Cep290)
Cep290 (Mus musculus)
Atf4 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 7 67.20 Quite High
Thalamus 1 52.44 Quite High
midbrain 1 51.92 Quite High
medulla 2 29.68 Quite Low
Sicca syndrome 6 5.00 Very Low Very Low Very Low
Spinal cord 5 5.00 Very Low Very Low Very Low
Bile 2 5.00 Very Low Very Low Very Low
peripheral neuropathy 2 5.00 Very Low Very Low Very Low
Action potential 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Polycystic Kidney Disease 1 97.68 Very High Very High Very High
Syndrome 33 93.92 High High
Cerebellar Ataxia 48 92.96 High High
Ataxia 92 87.76 High High
Muscle Hypotonia 2 80.32 Quite High
Cerebellar Diseases 1 75.52 Quite High
Dysarthria 9 70.80 Quite High
Ocular Toxicity (including Many Sub-types) 9 69.84 Quite High
Tremor 1 68.64 Quite High
Disease 31 63.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CEP290 or NPHP6 encodes for nephrocystin-6, a centrosomal protein that modulates the activity of ATF4, a transcription factor implicated in the cAMP-dependent renal cyst formation.

nephrocystin-6 Regulation (modulates) of ATF4 associated with polycystic kidney disease
1) Confidence 0.04 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1664553 Disease Relevance 1.96 Pain Relevance 0.09

General Comments

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