INT199792

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Context Info
Confidence 0.41
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.55
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP2A6) endoplasmic reticulum (CYP2A6) enzyme binding (CYP2A6)
Anatomy Link Frequency
alveolar macrophages 2
CYP2A6 (Homo sapiens)
Pain Link Frequency Relevance Heat
opiate 5 51.20 Quite High
Nicotine 34 5.00 Very Low Very Low Very Low
Dopamine 14 5.00 Very Low Very Low Very Low
Nucleus accumbens 8 5.00 Very Low Very Low Very Low
addiction 6 5.00 Very Low Very Low Very Low
Ventral tegmentum 5 5.00 Very Low Very Low Very Low
Peripheral nervous system 5 5.00 Very Low Very Low Very Low
cocaine 4 5.00 Very Low Very Low Very Low
cannabis 4 5.00 Very Low Very Low Very Low
midbrain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lung Cancer 6 98.04 Very High Very High Very High
Nicotine Addiction 68 95.56 Very High Very High Very High
Repression 1 84.16 Quite High
Myelodysplastic Syndromes 16 5.00 Very Low Very Low Very Low
Vomiting 6 5.00 Very Low Very Low Very Low
Worm Infection 4 5.00 Very Low Very Low Very Low
Infection 4 5.00 Very Low Very Low Very Low
Pulmonary Disease 3 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low
Drug Dependence 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we detected expression of CYP2A6/7 in both alveolar macrophages and bronchial biopsy material, but we did not find any difference in regard to smoking status.
Negative_regulation (detected) of Gene_expression (expression) of CYP2A6 in alveolar macrophages associated with nicotine addiction
1) Confidence 0.41 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.55 Pain Relevance 0
For several key enzymes, CYP1A2, CYP2A6, CYP2C19 and CYP2E1, these ratios were particularly low (?
Negative_regulation (low) of Gene_expression (enzymes) of CYP2A6
2) Confidence 0.28 Published 2008 Journal Proceedings of the Royal Society B: Biological Sciences Section Body Doc Link PMC2367444 Disease Relevance 0 Pain Relevance 0.05

General Comments

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