INT19982

Context Info Confidence 0.58 First Reported 1990 Last Reported 2000 Negated 0 Speculated 0 Reported most in Abstract Documents 4 Total Number 8 Disease Relevance 1.96 Pain Relevance 0.77

mitochondrion (Lipf) extracellular region (Lipf)

Anatomy Link Frequency stomach 1 Lipf (Rattus norvegicus)

Pain Link Frequency Relevance Heat alcohol 6 97.24 Chronic pancreatitis 11 96.20

Disease Link Frequency Relevance Heat Exocrine Pancreatic Insufficiency 20 96.60 Pancreatitis 11 96.20 Duodenal Ulcer 3 85.04 Alcoholic Pancreatitis 3 75.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

CONCLUSIONS: The cephalic phase of gastric lipase secretion is impaired in ACP patients.

Localization (secretion) of gastric lipase

1) Confidence 0.58 Published 2000 Journal Scand. J. Gastroenterol. Section Body Doc Link 10720121 Disease Relevance 0 Pain Relevance 0

In that state the secretion of gastric lipase could be essential and compensate for the pancreatic defect.

Localization (secretion) of gastric lipase

2) Confidence 0.58 Published 2000 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 10720121 Disease Relevance 0.17 Pain Relevance 0.10

RESULTS: Sham feeding rapidly and significantly increased gastric lipase secretion in healthy volunteers, whereas ACP patients did not respond to sham feeding.

Localization (secretion) of gastric lipase

3) Confidence 0.58 Published 2000 Journal Scand. J. Gastroenterol. Section Body Doc Link 10720121 Disease Relevance 0 Pain Relevance 0

However, conflicting studies have not resolved the order of magnitude of gastric lipase secretion in these patients.

Localization (secretion) of gastric lipase

4) Confidence 0.58 Published 2000 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 10720121 Disease Relevance 0.16 Pain Relevance 0.09

Gastric lipase secretion could be increased in several clinical conditions and particularly in patients with pancreatic insufficiency caused by alcoholic chronic pancreatitis who have been abstinent for a long time.

Localization (secretion) of Gastric lipase associated with exocrine pancreatic insufficiency and chronic pancreatitis

5) Confidence 0.56 Published 1990 Journal Gastroenterology Section Abstract Doc Link 2111783 Disease Relevance 0.70 Pain Relevance 0.24

The aims of this study were to evaluate the amount of gastric lipase secreted by the stomach in normal adults and to elucidate a possible adaptative secretion of this enzyme in response to pancreatic insufficiency secondary to alcoholic chronic pancreatitis.

Localization (secreted) of gastric lipase in stomach associated with exocrine pancreatic insufficiency and chronic pancreatitis

6) Confidence 0.56 Published 1990 Journal Gastroenterology Section Abstract Doc Link 2111783 Disease Relevance 0.40 Pain Relevance 0.12

Secretory patterns of gastric lipase and pepsin were closely comparable.

Localization (Secretory) of gastric lipase

7) Confidence 0.52 Published 1990 Journal Gastroenterology Section Abstract Doc Link 2111783 Disease Relevance 0.52 Pain Relevance 0.23

Although their fundic cells continue to secrete gastric lipase, they are not subject to normal neuro-hormonal regulation.

Localization (secrete) of gastric lipase

8) Confidence 0.44 Published 2000 Journal Scand. J. Gastroenterol. Section Body Doc Link 10720121 Disease Relevance 0 Pain Relevance 0

General Comments

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