INT199851

Context Info Confidence 0.07 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.04 Pain Relevance 0.04

cytosol (Casp8) peptidase activity (Casp8) mitochondrion (Casp8) nucleus (Casp8) protein complex (Casp8) cytoplasm (Casp8)

Anatomy Link Frequency Cleavage 2 Casp8 (Mus musculus)

Pain Link Frequency Relevance Heat addiction 1 87.92 palliative 1 5.00 Thoracotomy 1 5.00 Versed 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 60 98.16 Death 14 92.28 Non-small-cell Lung Cancer 16 50.00 Lung Cancer 10 9.28 Cancer 46 5.00 Severe Combined Immunodeficiency 4 5.00 Reprotox - General 1 2 5.00 Leukemia 2 5.00 Toxicity 1 5.00 Osteogenic Sarcomas 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Cleavage of caspase-8 and Bid was low in KNS62 cells after GEM and PB treatment alone, but significantly increased with combination therapy (Fig. 3a).

Positive_regulation (increased) of Protein_catabolism (Cleavage) of caspase-8 in Cleavage

1) Confidence 0.07 Published 2006 Journal J Carcinog Section Body Doc Link PMC1665446 Disease Relevance 1.04 Pain Relevance 0.04

General Comments

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