INT200063

Context Info Confidence 0.44 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.45 Pain Relevance 0

plasma membrane (MAGED1, Ngfr) cytoplasm (MAGED1, Ngfr) signal transduction (Ngfr) nuclear envelope (Ngfr) Golgi apparatus (Ngfr) nucleus (Ngfr)

MAGED1 (Homo sapiens) Ngfr (Mus musculus)

Pain Link Frequency Relevance Heat Spinal cord 10 5.00 lumbar region 6 5.00 Sciatic nerve 6 5.00 Pain 4 5.00 Pain threshold 4 5.00 Eae 4 5.00 GABAergic 4 5.00 tail-flick 2 5.00 hyperexcitability 2 5.00 ketamine 2 5.00

Disease Link Frequency Relevance Heat Death 46 100.00 Fasciculation 4 72.60 Skin Cancer 2 53.16 Syndrome 14 49.04 Embryonal Carcinoma 2 46.80 Disease 4 44.40 Muscle Hypotonia 2 39.44 Apoptosis 50 36.48 Hyperphagia 2 36.48 Obesity 2 34.08

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Interestingly, it is not only Necdin but also other members of the family such as NRAGE and MAGEH1 which interact with the death domain of the low affinity receptor to neurotrophin p75NTR [5,12,14,15].

NRAGE Binding (interact) of low affinity receptor associated with death

1) Confidence 0.44 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.23 Pain Relevance 0

Interestingly, it is not only Necdin but also other members of the family such as NRAGE and MAGEH1 which interact with the death domain of the low affinity receptor to neurotrophin p75NTR [5,12,14,15].

NRAGE Binding (interact) of p75NTR associated with death

2) Confidence 0.34 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.23 Pain Relevance 0

General Comments

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