INT20011

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Context Info
Confidence 0.44
First Reported 1990
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 3.83
Pain Relevance 3.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NEUROD1) nucleus (NEUROD1) transcription factor binding (NEUROD1)
cytoplasm (NEUROD1)
Anatomy Link Frequency
PGE1 1
brain 1
adipocyte 1
NEUROD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 16 100.00 Very High Very High Very High
Dopamine 4 100.00 Very High Very High Very High
opiate 2 100.00 Very High Very High Very High
agonist 48 99.96 Very High Very High Very High
beta blocker 8 99.64 Very High Very High Very High
antagonist 3 99.60 Very High Very High Very High
Catecholamine 3 98.10 Very High Very High Very High
tolerance 2 97.64 Very High Very High Very High
analgesia 3 97.28 Very High Very High Very High
epidural 7 96.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Dyspnea 2 99.88 Very High Very High Very High
Tremor 1 99.30 Very High Very High Very High
Asthma 22 98.86 Very High Very High Very High
Heart Rate Under Development 5 96.08 Very High Very High Very High
Stress 6 95.32 Very High Very High Very High
Weight Loss 7 95.10 Very High Very High Very High
Pressure And Volume Under Development 3 95.04 Very High Very High Very High
Myocardial Infarction 7 94.56 High High
Headache 2 92.96 High High
Cough 69 92.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A dose-response effect was observed for serum beta 2-microglobulin, neopterin, and p78 (P less than 0.02).
Regulation (effect) of beta 2
1) Confidence 0.44 Published 1990 Journal Cancer Res. Section Abstract Doc Link 2114942 Disease Relevance 0.28 Pain Relevance 0.07
The affinity for several other rat brain receptors such as 5-HT1A, alpha 2-adrenergic, dopamine D1, muscarinic M1 and M2, opiate sigma and beta 2-adrenergic was low.
Regulation (affinity) of beta 2 in brain associated with dopamine and opiate
2) Confidence 0.44 Published 1990 Journal Pharmacol. Toxicol. Section Abstract Doc Link 2154737 Disease Relevance 0 Pain Relevance 0.32
Tremor is usually the dose-limiting side effect for the beta-2 selective agents.
Regulation (effect) of beta-2 associated with tremor
3) Confidence 0.44 Published 1995 Journal AACN Clin Issues Section Abstract Doc Link 7743429 Disease Relevance 0.72 Pain Relevance 0.34
Finally, we examined the effect of the bradykinin beta 2 receptor antagonist Hoe 140 and the thromboxane prostanoid (TP) receptor blocking drug GR32191 on BK-induced responses.
Spec (examined) Regulation (effect) of beta 2 associated with antagonist and bradykinin
4) Confidence 0.44 Published 1994 Journal Am. J. Respir. Crit. Care Med. Section Abstract Doc Link 7921430 Disease Relevance 0.07 Pain Relevance 0.84
Definitions used for clinical management pathway

• Asthma: Recurrent (>2) episodes of wheeze and/or dyspnoea that responds (within mins) to inhaled beta2 agonist, or bronchodilator resposiveness documented on spirometry (?

Regulation (responds) of beta2 associated with asthma, agonist and dyspnea
5) Confidence 0.42 Published 2010 Journal Trials Section Body Doc Link PMC2989328 Disease Relevance 1.19 Pain Relevance 0.05
The value of urine beta 2-microglobulin in the NIC group was larger than that in the PGE1 or SNP group.
Regulation (value) of beta 2 in PGE1
6) Confidence 0.26 Published 2000 Journal Masui Section Abstract Doc Link 11193508 Disease Relevance 0.39 Pain Relevance 0.74
We studied the effects of celiprolol, a cardioselective beta blocker with a stimulant effect on beta2 receptors.
Regulation (effect) of beta2 associated with beta blocker
7) Confidence 0.26 Published 2000 Journal Am. J. Cardiol. Section Abstract Doc Link 10856394 Disease Relevance 0.26 Pain Relevance 0.21
The distribution of other cell surface molecules such as NCAM or GABAA receptor beta2/3 subunits was not modified by strychnine treatment.
Neg (not) Regulation (modified) of beta2
8) Confidence 0.26 Published 1998 Journal J. Cell. Sci. Section Abstract Doc Link 9427682 Disease Relevance 0 Pain Relevance 0.10
This lack of a hypokalaemic effect might be partly due to reduced responsiveness of beta 2-adrenoceptors to adrenaline.
Regulation (responsiveness) of beta 2
9) Confidence 0.26 Published 1995 Journal Eur J Anaesthesiol Section Abstract Doc Link 8542857 Disease Relevance 0.30 Pain Relevance 0.41
In conclusion, weight reduction leads to increased efficiency of adipocyte lipolysis with decreased resting lipolysis rate but increased sensitivity to stimulation by catecholamines, which may be attributed to a decreased activity of hormone-sensitive lipase and an increased sensitivity of beta 2-adrenoceptors.
Regulation (sensitivity) of beta 2 in adipocyte associated with weight loss and catecholamine
10) Confidence 0.26 Published 1995 Journal Clin. Sci. Section Abstract Doc Link 7493443 Disease Relevance 0.63 Pain Relevance 0.34
Both fade and tachyphylaxis reflect down regulation of receptor, suggesting that ascorbate prevents down regulation of beta 2 adrenergic receptors and may, under some conditions, reverse it (Figures 4, 5, 6).
Regulation (regulation) of beta 2
11) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001466 Disease Relevance 0 Pain Relevance 0.11

General Comments

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