INT200268

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Context Info
Confidence 0.39
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.80
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Sp3) intracellular (Sp3) DNA binding (Sp3)
Anatomy Link Frequency
neuronal 2
Sp3 (Mus musculus)
Pain Link Frequency Relevance Heat
mu opioid receptor 80 74.56 Quite High
cytokine 13 62.40 Quite High
Central nervous system 1 41.20 Quite Low
Inflammation 4 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Morphine 3 5.00 Very Low Very Low Very Low
opioid receptor 3 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
IPN 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 14 99.82 Very High Very High Very High
Disease 7 98.62 Very High Very High Very High
Neurodegenerative Disease 1 60.64 Quite High
Targeted Disruption 2 57.44 Quite High
Atherosclerosis 11 5.00 Very Low Very Low Very Low
INFLAMMATION 7 5.00 Very Low Very Low Very Low
Obesity 2 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 2 5.00 Very Low Very Low Very Low
Disorder Of Lipid Metabolism 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is probable that the silencing of NRSF target genes in Huntinton's disease could also be the result of additive or synergic repression through increasing interaction with Sp3 or other transcriptional factors resulting from abnormal presence of NRSF in neuronal cells.
Positive_regulation (increasing) of Sp3 Binding (interaction) of in neuronal associated with repression and disease
1) Confidence 0.39 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0.80 Pain Relevance 0.07
PKB-mediated phosphorylation of rhSp1 had no effect on DNA binding (data not shown), thereby suggesting that a downstream kinase(s) was potentially mediating the actions of PKB on Sp1/Sp3 binding.
Positive_regulation (actions) of Sp1/Sp3 Binding (binding) of
2) Confidence 0.33 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0.03

General Comments

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