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Context Info
Confidence 0.58
First Reported 1983
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 19
Total Number 23
Disease Relevance 15.49
Pain Relevance 4.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CRTAC1) proteinaceous extracellular matrix (CRTAC1)
Anatomy Link Frequency
astrocytes 3
oligodendrocytes 2
retinas 1
smooth muscle 1
medulla 1
CRTAC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Peripheral nervous system 4 99.92 Very High Very High Very High
Inflammatory response 2 99.20 Very High Very High Very High
Pain 8 99.14 Very High Very High Very High
substance P 1 99.04 Very High Very High Very High
Enkephalin 9 98.24 Very High Very High Very High
Ventral tegmentum 3 97.88 Very High Very High Very High
medulla 1 97.52 Very High Very High Very High
Inflammation 8 96.76 Very High Very High Very High
Cancer pain 1 95.28 Very High Very High Very High
cytokine 17 94.68 High High
Disease Link Frequency Relevance Heat
Cancer 36 99.76 Very High Very High Very High
Encephalitis 2 99.42 Very High Very High Very High
Pain 7 99.14 Very High Very High Very High
INFLAMMATION 8 99.02 Very High Very High Very High
Primary Sclerosing Cholangitis 8 98.90 Very High Very High Very High
Bone Cancer 4 98.46 Very High Very High Very High
Necrosis 2 98.20 Very High Very High Very High
Primitive Neuroectodermal Tumors 4 98.16 Very High Very High Very High
Apoptosis 9 97.00 Very High Very High Very High
Hypercapnia 5 96.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Risedronate decreased bone cancer-related bone destruction and pain-related behavior and decreased the spinal expression of glial fibrillary acidic protein, whereas NE-10790 had no effect on these parameters.
Gene_expression (expression) of acidic protein in spinal associated with pain and bone cancer
1) Confidence 0.58 Published 2009 Journal Int. J. Cancer Section Abstract Doc Link 19444917 Disease Relevance 1.26 Pain Relevance 0.40
Slight glial fibrillary acidic protein staining was detected in only one of the three retinas from rabbits in the repeated injection group.
Gene_expression (detected) of acidic protein in retinas
2) Confidence 0.45 Published 2009 Journal Retina (Philadelphia, Pa.) Section Body Doc Link 18626418 Disease Relevance 0 Pain Relevance 0
Immunohistochemically, the tumor cells were positive for synaptophysin, nestin, microtubule-associated protein-2, CD56, CD10, glial fibrillary acidic protein (focal), and S-100 protein (focal).
Gene_expression (positive) of acidic protein associated with cancer
3) Confidence 0.13 Published 2007 Journal Pathol. Int. Section Abstract Doc Link 17300673 Disease Relevance 1.10 Pain Relevance 0.20
Immunohistochemically, the neoplastic cells of both papillary structures and pseudorosettes were positive for glial fibrillary acidic protein and vimentin, whereas they were only slightly immunoreactive for epithelial membrane antigen and negative for cytokeratins.
Gene_expression (positive) of acidic protein
4) Confidence 0.04 Published 2009 Journal Folia Neuropathol Section Abstract Doc Link 20054788 Disease Relevance 1.28 Pain Relevance 0.15
-gal/anti-glial fibrillary acidic protein (GFAP, 1?
Gene_expression (anti) of acidic protein
5) Confidence 0.03 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2092394 Disease Relevance 0 Pain Relevance 0.03
One of the cell lines, HM3.B10 (B10), was found to differentiate into neural cell types including neural stem cells, neurons, astrocytes and oligodendrocytes in vitro as shown by expression of genetic markers for neural stem cells (nestin and Musashi1), neurons (neurofilament protein, synapsin and MAP2), astrocytes (glial fibrillary acidic protein, GFAP) and oligodendrocytes (myelin basic protein, MBP) as determined by RT-PCR assay.
Gene_expression (expression) of acidic protein in astrocytes
6) Confidence 0.03 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC2092394 Disease Relevance 0.67 Pain Relevance 0.18
The rosettes were consistently synaptophysin and MAP-2 immunoreactive, whereas the spindle cells were positive for S-100 protein and glial fibrillary acidic protein.
Gene_expression (positive) of acidic protein in spindle cells
7) Confidence 0.02 Published 2002 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 11979088 Disease Relevance 0.70 Pain Relevance 0.05
Relative to drug-naive Fischer 344 rats, drug-naive Dark Agouti rats showed higher levels of tyrosine hydroxylase and glial fibrillary acidic protein, and lower levels of neurofilament proteins, in the ventral tegmental area.
Gene_expression (levels) of acidic protein in ventral associated with ventral tegmentum
8) Confidence 0.02 Published 1999 Journal Neuroscience Section Abstract Doc Link 10336139 Disease Relevance 0.22 Pain Relevance 0.55
A premortem diagnosis was established in the first patient with the aid of peroxidase-antiperoxidase staining of the bone marrow biopsy specimen for glial fibrillary acidic protein, a glial-specific marker.
Gene_expression (staining) of acidic protein in bone marrow
9) Confidence 0.02 Published 1983 Journal Ann. Neurol. Section Abstract Doc Link 6316836 Disease Relevance 1.05 Pain Relevance 0.09
Expressions of glial fibrillary acidic protein and aquaporin 4 (AQP4) were weakened in the area of Schwann cell remyelination, suggesting that the essential pathogenesis of this case was disturbance of astrocytes.
Gene_expression (Expressions) of acidic protein in Schwann cell
10) Confidence 0.01 Published 2010 Journal Neuropathology Section Abstract Doc Link 19925565 Disease Relevance 0.80 Pain Relevance 0.53
One of the cell lines, HM3.B10 (B10), was found to differentiate into neural cell types including neural stem cells, neurons, astrocytes and oligodendrocytes in vitro as shown by expression of genetic markers for neural stem cells (nestin and Musashi1), neurons (neurofilament protein, synapsin and MAP2), astrocytes (glial fibrillary acidic protein, GFAP) and oligodendrocytes (myelin basic protein, MBP) as determined by RT-PCR assay.
Gene_expression (expression) of acidic protein in neurons
11) Confidence 0.01 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC2092394 Disease Relevance 0.67 Pain Relevance 0.18
One of the cell lines, HM3.B10 (B10), was found to differentiate into neural cell types including neural stem cells, neurons, astrocytes and oligodendrocytes in vitro as shown by expression of genetic markers for neural stem cells (nestin and Musashi1), neurons (neurofilament protein, synapsin and MAP2), astrocytes (glial fibrillary acidic protein, GFAP) and oligodendrocytes (myelin basic protein, MBP) as determined by RT-PCR assay.
Gene_expression (expression) of acidic protein in stem cells
12) Confidence 0.01 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC2092394 Disease Relevance 0.67 Pain Relevance 0.18
One of the cell lines, HM3.B10 (B10), was found to differentiate into neural cell types including neural stem cells, neurons, astrocytes and oligodendrocytes in vitro as shown by expression of genetic markers for neural stem cells (nestin and Musashi1), neurons (neurofilament protein, synapsin and MAP2), astrocytes (glial fibrillary acidic protein, GFAP) and oligodendrocytes (myelin basic protein, MBP) as determined by RT-PCR assay.
Gene_expression (expression) of acidic protein in oligodendrocytes
13) Confidence 0.01 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC2092394 Disease Relevance 0.67 Pain Relevance 0.18
Immunohistochemistry revealed a CD3(+) T-cell dominated inflammatory response with intralesional reactive astrocytes expressing glial fibrillary acidic protein.
Gene_expression (expressing) of acidic protein in astrocytes associated with inflammatory response
14) Confidence 0.01 Published 2010 Journal J. Comp. Pathol. Section Abstract Doc Link 19815229 Disease Relevance 0.53 Pain Relevance 0.18
Immunohistochemical study showed that the primitive germ cells were positive for placental alkaline phosphatase, alpha-fetoprotein, cytokeratin, vimentin, but negative for glial fibrillary acidic protein.
Neg (negative) Gene_expression (negative) of acidic protein in primitive germ cells
15) Confidence 0.01 Published 2009 Journal Clin Neurol Neurosurg Section Abstract Doc Link 19540038 Disease Relevance 0.92 Pain Relevance 0.07
The tumour was characterized immunohistochemically by the presence of neurofilament protein, glial fibrillary acidic protein, S-100 protein, neuron-specific enolase, chromogranin A, ACTH, leu-enkephalin and vasoactive intestinal polypeptide, and ultrastructurally by demonstration of neurosecretory granules and paranuclear intermediate filament whorls.
Gene_expression (presence) of acidic protein in filament associated with cancer and enkephalin
16) Confidence 0.01 Published 1990 Journal Virchows Arch A Pathol Anat Histopathol Section Abstract Doc Link 2117315 Disease Relevance 0.43 Pain Relevance 0.10
Immunohistochemical staining revealed diffuse expression of synaptophysin and neurofilament protein, and focal expression of glial fibrillary acidic protein, S-100 protein, desmin, and myoglobin.
Gene_expression (expression) of acidic protein
17) Confidence 0.01 Published 2008 Journal Brain Tumor Pathol Section Abstract Doc Link 18415665 Disease Relevance 0.71 Pain Relevance 0.09
Autoimmune encephalomyelitis was induced by the adoptive transfer of CD4+ T-line cells specific for either myelin basic protein, myelin oligodendrocyte glycoprotein (MOG), myelin-associated glycoprotein, S100 beta, or glial fibrillary acidic protein.
Gene_expression (transfer) of acidic protein in oligodendrocyte associated with encephalitis
18) Confidence 0.01 Published 1997 Journal Lab. Invest. Section Abstract Doc Link 9121118 Disease Relevance 0.75 Pain Relevance 0.45
The immunoreactive expression of glial fibrillary acidic protein, tyrosine hydroxylase, substance P and met-enkephalin in the medulla was also not different between the three groups.
Gene_expression (expression) of acidic protein in medulla associated with medulla, enkephalin and substance p
19) Confidence 0.00 Published 2002 Journal Reprod. Fertil. Dev. Section Abstract Doc Link 12051528 Disease Relevance 0.86 Pain Relevance 0.20
However, the expression of other genes such as epidermal growth factor-receptor, glial fibrillary acidic protein, and several proto-oncogenes (src, fos and myc), and a cholinergic marker such as choline acetyltransferase activity were unaltered.
Gene_expression (expression) of acidic protein
20) Confidence 0.00 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7854069 Disease Relevance 0 Pain Relevance 0.20

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