INT200556

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Context Info
Confidence 0.28
First Reported 2006
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 6.04
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Kdr) kinase activity (Kdr) cytoplasm (Kdr)
Anatomy Link Frequency
blood vessels 1
endothelial cells 1
bone marrow 1
lung 1
Kdr (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 411 99.80 Very High Very High Very High
Inflammatory response 6 99.68 Very High Very High Very High
Inflammation 10 89.72 High High
ischemia 57 81.96 Quite High
cytokine 8 25.12 Quite Low
anesthesia 9 22.24 Low Low
antagonist 6 14.20 Low Low
Pain 8 5.00 Very Low Very Low Very Low
Arthritis 6 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 17 99.68 Very High Very High Very High
Cancer 522 99.36 Very High Very High Very High
Targeted Disruption 81 96.76 Very High Very High Very High
Lung Injury 9 92.32 High High
Wound Healing 16 90.48 High High
Acute Liver Failure 22 89.20 High High
Skin Cancer 9 83.92 Quite High
Apoptosis 29 82.48 Quite High
Cv Unclassified Under Development 51 81.96 Quite High
Injury 41 80.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The scVEGF-based family of probes has been validated to target the VEGF receptor in vitro and in vivo tumor angiogenesis [90, 91].
Regulation (target) of VEGF receptor associated with cancer
1) Confidence 0.28 Published 2010 Journal Angiogenesis Section Body Doc Link PMC2911541 Disease Relevance 0.76 Pain Relevance 0.23
As expected, no significant changes in either mRNA or protein levels of Rac1 or Flk-1 were observed in pSico-Con infected cells (Figure 2B).
Neg (no) Regulation (changes) of Flk-1
2) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.47 Pain Relevance 0
The VEGFR-2 is a very attractive endothelial target for imaging of tumor angiogenesis due to its temporal and local upregulation during (tumor-)angiogenesis [24–28].
Regulation (target) of VEGFR-2 associated with cancer and imagery
3) Confidence 0.17 Published 2010 Journal Angiogenesis Section Body Doc Link PMC2911541 Disease Relevance 0.83 Pain Relevance 0.15
To target the VEGFR-2, Backer et al. [88] used single chain VEGF (scVEGF) with an N-terminal cysteine-containing tag (Cys-tag) which can be used for site specific attachment of various agents [89].
Regulation (target) of VEGFR-2
4) Confidence 0.17 Published 2010 Journal Angiogenesis Section Body Doc Link PMC2911541 Disease Relevance 0.82 Pain Relevance 0.16
In this mouse, luciferase expression is under control of the VEGFR2 promoter region [30] causing endothelial cells lining the angiogenic blood vessels to express luciferase.
Regulation (control) of VEGFR2 in blood vessels
5) Confidence 0.17 Published 2010 Journal Angiogenesis Section Body Doc Link PMC2911541 Disease Relevance 0.49 Pain Relevance 0.13
Effects of VEGFR-mAbs on the serum ALT and survival rate
Regulation (Effects) of VEGFR
6) Confidence 0.06 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2933582 Disease Relevance 0.53 Pain Relevance 0
This phenomenon indicates that the function of VEGFR-2 may be altered by the inflammatory responses in the lung tissue.
Spec (may) Regulation (altered) of VEGFR in lung associated with inflammatory response
7) Confidence 0.05 Published 2006 Journal Crit Care Section Body Doc Link PMC1751039 Disease Relevance 0.35 Pain Relevance 0.09
One of the first observations that bone marrow contains high numbers of endothelial progenitor cells was by Ashara et al using infusion of bone marrow cells in which the beta-galactosidase marker was expressed under control of endothelial cell-specific promoters such as Flk-1 and Tie-2.
Regulation (control) of Flk-1 in bone marrow
8) Confidence 0.03 Published 2008 Journal J Transl Med Section Body Doc Link PMC2533293 Disease Relevance 0.61 Pain Relevance 0.22
Their approach relied on using agents that directly target vascular endothelial growth factor (VEGF) or its receptor (VEGFR) on endothelial cells.
Regulation (target) of VEGFR in endothelial cells
9) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716529 Disease Relevance 1.18 Pain Relevance 0.03

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