INT200757

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Context Info
Confidence 0.20
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.27
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Fig4) endosome (Fig4) cell death (Fig4)
Golgi apparatus (Fig4) endoplasmic reticulum (Fig4)
Fig4 (Mus musculus)
Pain Link Frequency Relevance Heat
diclofenac 95 94.80 High High
chemokine 2 90.44 High High
antagonist 1 59.44 Quite High
Glutamate 29 54.32 Quite High
imagery 6 51.20 Quite High
COX-2 inhibitor 6 46.00 Quite Low
Nortriptyline 1 33.92 Quite Low
Desipramine 1 32.72 Quite Low
Serotonin 8 18.92 Low Low
Dopamine 4 17.76 Low Low
Disease Link Frequency Relevance Heat
Cancer 125 99.44 Very High Very High Very High
Disease 65 87.32 High High
Targeted Disruption 4 86.96 High High
Ganglion Cysts 4 76.08 Quite High
Pancreatic Cancer 13 68.00 Quite High
Toxicity 5 53.52 Quite High
Adhesions 2 12.64 Low Low
Apoptosis 17 5.00 Very Low Very Low Very Low
INFLAMMATION 15 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We isolated GFP positive cells from tumors and found that these cells express high levels of arginase 1 (Fig S3).
Gene_expression (express) of Fig S3 associated with cancer
1) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939880 Disease Relevance 0.89 Pain Relevance 0.29
After 2-days post-injection, ocular tissues were isolated as described above and examined for EGFP mRNA expression by qRT-PCR (Fig 4).
Spec (examined) Gene_expression (expression) of Fig 4
2) Confidence 0.13 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762345 Disease Relevance 0.08 Pain Relevance 0
Thus, neuroprotective effects of Dimebon observed in our experiments (Table 1, Fig 5C) most likely can be explained by "Ca2+ stabilizing" effects of Dimebon resulting from inhibition of NMDAR (Fig 3) and voltage-gated Ca2+ channels (Fig 4).
Gene_expression (channels) of Fig 4
3) Confidence 0.09 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2577671 Disease Relevance 0.30 Pain Relevance 0.08

General Comments

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