INT200811

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Context Info
Confidence 0.30
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.77
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Akt1) aging (Akt1) enzyme binding (Akt1)
carbohydrate metabolic process (Akt1) cytoplasm (Akt1) cytosol (Akt1)
Anatomy Link Frequency
fat 1
Epo (Mus musculus)
Akt1 (Mus musculus)
Pain Link Frequency Relevance Heat
cva 5 67.92 Quite High
fibrosis 11 62.32 Quite High
Inflammatory response 22 52.56 Quite High
Inflammation 8 23.12 Low Low
cytokine 9 15.92 Low Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
Parenteral administration 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 9 99.40 Very High Very High Very High
Erythrocytosis 35 96.72 Very High Very High Very High
Myelodysplastic Syndromes 62 95.00 High High
Malignant Neoplastic Disease 1 91.32 High High
Myelofibrosis 18 85.56 High High
Reticulocytosis 5 71.60 Quite High
Hemorrhage 16 67.92 Quite High
Pressure And Volume Under Development 2 66.80 Quite High
Hematological Disease 4 65.36 Quite High
Apoptosis 68 62.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
EPO induced a dose-dependent increase in the expression levels of bFGF, IGF-1, PDGF-BB, MMP-2, PKB, and phosphoPKB (Figure 3B).
EPO Positive_regulation (increase) of PKB
1) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981551 Disease Relevance 0.31 Pain Relevance 0.06
In addition, EPO increased PKB expression and activity in the fat grafts, and PKB is critical for the cellular pathway of a broad spectrum of growth factors.
EPO Positive_regulation (increased) of PKB in fat
2) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981551 Disease Relevance 0.05 Pain Relevance 0
Epo stimulation activates Src family kinases including Lyn [28], while a Src kinase inhibitor impaired the Epo-independent differentiation of erythroid progenitors from PV patients [12].
Epo Positive_regulation (activates) of kinases associated with myelodysplastic syndromes
3) Confidence 0.22 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762384 Disease Relevance 1.41 Pain Relevance 0.03

General Comments

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