INT200813

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Context Info
Confidence 0.26
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.46
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Jak2, Akt1) cytosol (Jak2, Akt1) signal transduction (Jak2, Akt1)
nucleus (Jak2, Akt1) kinase activity (Jak2, Akt1) cell differentiation (Jak2)
Jak2 (Mus musculus)
Akt1 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 3 53.32 Quite High
cytokine 3 5.00 Very Low Very Low Very Low
Parenteral administration 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Erythrocytosis 35 99.40 Very High Very High Very High
Myelodysplastic Syndromes 62 95.80 Very High Very High Very High
Disease 9 89.60 High High
Myelofibrosis 18 82.72 Quite High
Hematological Disease 4 73.08 Quite High
Reticulocytosis 5 62.16 Quite High
Fibrosis 3 53.32 Quite High
Sprains And Strains 13 50.20 Quite High
Congenital Anomalies 10 42.96 Quite Low
Hemorrhage 10 31.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although Src kinases are activated by JAK2 in erythroid cells upon Epo stimulation [28] and a Src inhibitor impaired Epo-independent maturation of PV erythroid progenitors [13], we demonstrated that polycythemia induced by JAK2 V617F was independent of Lyn, Hck, and Fgr, the three principal Src family kinases expressed in myeloerythroid cells.
JAK2 Positive_regulation (activated) of kinases associated with erythrocytosis and myelodysplastic syndromes
1) Confidence 0.26 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762384 Disease Relevance 1.46 Pain Relevance 0.03

General Comments

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