INT201222

Context Info Confidence 0.45 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.51 Pain Relevance 0.93

small molecule metabolic process (STX1A) vesicle-mediated transport (STX1A) extracellular region (STX1A) plasma membrane (STX1A) protein binding, bridging (STX1A) protein complex (STX1A)

Anatomy Link Frequency lamina 1 STX1A (Homo sapiens)

Pain Link Frequency Relevance Heat spinothalamic 4 99.96 burning pain 1 95.88 Cold hyperalgesia 1 85.92 spinal dorsal horn 1 78.88 allodynia 10 77.44 c fibre 4 74.88 nociceptor 2 68.60 Pain 25 57.16 Hyperalgesia 1 53.60 agonist 2 36.44

Disease Link Frequency Relevance Heat Pain 23 95.88 Hyperalgesia 2 85.52 Nociception 5 85.16 Neuropathic Pain 11 77.44 Hypersensitivity 4 5.00 Facial Pain 3 5.00 Stress 2 5.00 INFLAMMATION 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Even in the presence of menthol it seems 24°C does not provide input of sufficient magnitude to increase HPC STT cell activity beyond cool-sensitive STT cells in lamina I and thus could explain why menthol did not enhance sensitivity to 24°C.

Positive_regulation (increase) of HPC in lamina associated with spinothalamic

1) Confidence 0.45 Published 2006 Journal Mol Pain Section Body Doc Link PMC1764875 Disease Relevance 0.51 Pain Relevance 0.93

General Comments

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