INT201565

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 5.94
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (NPC1) nuclear envelope (NPC1) endoplasmic reticulum (NPC1)
lysosome (NPC1)
Anatomy Link Frequency
lymph nodes 2
plasma 2
NPC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
GABAergic 14 94.48 High High
metalloproteinase 2 90.12 High High
Intracerebroventricular 6 66.36 Quite High
Hippocampus 26 54.96 Quite High
long-term potentiation 6 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Neuropeptide 4 5.00 Very Low Very Low Very Low
Eae 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nasopharynx Cancer 394 100.00 Very High Very High Very High
Epstein-barr Virus 107 100.00 Very High Very High Very High
Neurodegenerative Disease 54 99.96 Very High Very High Very High
Cancer 139 99.24 Very High Very High Very High
Disease 46 97.72 Very High Very High Very High
Apoptosis 28 95.88 Very High Very High Very High
Infection 16 93.96 High High
Convulsion 78 91.68 High High
Metastasis 23 90.88 High High
Carcinoma 19 69.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While substantial amount of information on the genomic alteration of NPC have been
Positive_regulation (alteration) of Gene_expression (alteration) of NPC associated with nasopharynx cancer
1) Confidence 0.43 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 0.84 Pain Relevance 0
Measuring the expression of latent EBV genes in NPC and normal nasopharyngeal tissue samples, it was shown that deregulation of key proteins involving in apoptosis (bcl-2 related protein A1 and Fas apoptotic inhibitory molecule), cell cycle checkpoints (AKIP, SCYL1 and NIN) and metastasis (matrix metalloproteinase 1) were closely correlated with the levels of EBV gene expression in NPC [77].
Positive_regulation (Measuring) of Gene_expression (expression) of NPC associated with nasopharynx cancer, metalloproteinase, epstein-barr virus, apoptosis and metastasis
2) Confidence 0.37 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1774581 Disease Relevance 1.94 Pain Relevance 0.05
Combining the overall answers given regarding early symptoms and incidence, we think GPs often do not consider NPC when they see a patient with enlarged neck lymph nodes or other symptoms suspicious for NPC.
Neg (not) Positive_regulation (consider) of Neg (not) Gene_expression (consider) of NPC in lymph nodes associated with nasopharynx cancer
3) Confidence 0.36 Published 2010 Journal BMC Med Educ Section Body Doc Link PMC2998508 Disease Relevance 1.16 Pain Relevance 0
Additional investigations will be required on patient plasma samples - both NPC and controls - in order to address 2 questions: 1) Are concentrations of BART miRNAs consistently greater in the plasma of NPC patients by comparison with healthy carriers and patients bearing non-NPC tumors ?
Positive_regulation (required) of Gene_expression (samples) of NPC in plasma associated with cancer and nasopharynx cancer
4) Confidence 0.12 Published 2010 Journal Virol J Section Body Doc Link PMC2974674 Disease Relevance 1.28 Pain Relevance 0
Overall, these preliminary findings suggest that enhanced expression of NPC survivin may increase neurogenesis.


Spec (may) Positive_regulation (increase) of Gene_expression (expression) of NPC associated with neurodegenerative disease
5) Confidence 0.02 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2817683 Disease Relevance 0.36 Pain Relevance 0.11
Overall, these preliminary findings suggest that enhanced expression of NPC survivin may increase neurogenesis.


Positive_regulation (enhanced) of Gene_expression (expression) of NPC associated with neurodegenerative disease
6) Confidence 0.02 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2817683 Disease Relevance 0.36 Pain Relevance 0.11

General Comments

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