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Context Info
Confidence 0.40
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 24
Disease Relevance 21.60
Pain Relevance 2.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Cdk5r1) plasma membrane (Cdk5r1) nucleus (Cdk5r1)
embryo development (Cdk5r1) cell cycle (Cdk5r1) kinase activity (Cdk5r1)
Anatomy Link Frequency
neuronal 3
neurons 3
cleavage 2
hippocampus 1
Cdk5r1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 111 99.84 Very High Very High Very High
ischemia 129 99.56 Very High Very High Very High
depression 96 95.04 Very High Very High Very High
Eae 40 94.96 High High
Central nervous system 46 94.00 High High
Neuronal excitability 187 92.68 High High
Pyramidal cell 41 91.36 High High
cerebral cortex 1 83.60 Quite High
Substantia nigra 4 74.64 Quite High
Inflammation 75 68.24 Quite High
Disease Link Frequency Relevance Heat
Disease 481 99.96 Very High Very High Very High
Shock 121 99.96 Very High Very High Very High
Cv Unclassified Under Development 75 99.56 Very High Very High Very High
Convulsion 750 99.42 Very High Very High Very High
Neuroblastoma 4 99.40 Very High Very High Very High
Status Epilepticus 77 99.32 Very High Very High Very High
Drug Induced Neurotoxicity 28 99.28 Very High Very High Very High
Death 342 98.54 Very High Very High Very High
Sclerosis 26 97.84 Very High Very High Very High
Apoptosis 430 95.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Kainate-induced status epilepticus led to 5.0±2.7- and 3.9±1.3-fold increases in p25 level and p25/p35 ratio, respectively (Figure 7A, left).
Positive_regulation (increases) of p25 associated with status epilepticus
1) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 1.50 Pain Relevance 0.11
Similarly, pilocarpine-induced status epilepticus caused 2.8±0.8- and 2.5±0.6-fold increases in p25 level and p25/p35 ratio (Figure 7A, right).
Positive_regulation (increases) of p25 associated with status epilepticus
2) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 1.52 Pain Relevance 0.14
Similarly, pilocarpine-induced status epilepticus caused 2.8±0.8- and 2.5±0.6-fold increases in p25 level and p25/p35 ratio (Figure 7A, right).
Positive_regulation (increases) of p35 associated with status epilepticus
3) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 1.53 Pain Relevance 0.14
Kainate-induced status epilepticus led to 5.0±2.7- and 3.9±1.3-fold increases in p25 level and p25/p35 ratio, respectively (Figure 7A, left).
Positive_regulation (increases) of p35 associated with status epilepticus
4) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 1.51 Pain Relevance 0.11
The findings suggest that both pharmacologically- and electrically-induced epileptiform activity results in accumulation of the Cdk5 activating cofactor, p25.


Positive_regulation (accumulation) of p25
5) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 1.39 Pain Relevance 0.24
Similarly, pilocarpine-induced status epilepticus caused 2.8±0.8- and 2.5±0.6-fold increases in p25 level and p25/p35 ratio (Figure 7A, right).
Positive_regulation (increases) of p25 associated with status epilepticus
6) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 1.52 Pain Relevance 0.14
Kainate-induced status epilepticus led to 5.0±2.7- and 3.9±1.3-fold increases in p25 level and p25/p35 ratio, respectively (Figure 7A, left).
Positive_regulation (increases) of p25 associated with status epilepticus
7) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 1.51 Pain Relevance 0.11
Acute electroconvulsive shock resulted in time-dependent accumulation in p25 in hippocampus (Figure 7B).
Positive_regulation (accumulation) of p25 in hippocampus associated with shock and hippocampus
8) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 1.26 Pain Relevance 0.22
Enhanced CDK-5 activity and expression of p35 are associated with differentiation of cultured neuronal cells as well as accelerated neurite outgrowth [4].
Positive_regulation (Enhanced) of p35 in neuronal
9) Confidence 0.29 Published 2007 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC1802865 Disease Relevance 0.25 Pain Relevance 0.03
For instance, the cyclin-dependent kinase 5 (Cdk5) activator, p35, is cleaved to p25 by calpain [3,4], and the generated p25 hyperactivates Cdk5, possibly leading to neurodegeneration.
Positive_regulation (generated) of p25
10) Confidence 0.27 Published 2008 Journal Mol Brain Section Body Doc Link PMC2561015 Disease Relevance 0.16 Pain Relevance 0.07
Sixty minutes following electroconvulsive shock, p25 levels increased 2.47±0.08-fold.
Positive_regulation (increased) of p25 associated with shock
11) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 1.39 Pain Relevance 0.23
Induced-seizures in wild-type animals led to elevated amounts of p25, the Cdk5-activating cofactor.
Positive_regulation (elevated) of p25 associated with convulsion
12) Confidence 0.27 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2695674 Disease Relevance 0.43 Pain Relevance 0.08
In this study we show that chemically-induced status epilepticus and electroconvulsive shock in healthy animals induced acute generation of a Cdk5-activating cofactor, p25.
Positive_regulation (generation) of p25 associated with shock and status epilepticus
13) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 1.40 Pain Relevance 0.17
This is strongly reminiscent of our observations in inducible p25 mice that suffer a profound hippocampal and cortical sclerosis with pathological characteristics very similar to the AAV-Tau mice [28].
Positive_regulation (inducible) of p25 associated with sclerosis
14) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2748684 Disease Relevance 0.71 Pain Relevance 0.04
At this time point, the level of p25 protein was also increased in the ischemic hemisphere, compared to that of the control hemisphere (Figure 4B).
Positive_regulation (increased) of p25
15) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920814 Disease Relevance 0.17 Pain Relevance 0.04
We confirmed that CDK5/p25 activity is increased in the ischemic cerebral tissue as previously described [19], [21], [36].
Positive_regulation (increased) of p25
16) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920814 Disease Relevance 0.38 Pain Relevance 0.12
These data suggested that pMCAo induced cleavage of p35 to p25, with subsequent activation of CDK5/p25 activity.
Positive_regulation (activation) of p25 in cleavage
17) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920814 Disease Relevance 0.16 Pain Relevance 0.04
The p25 fragment triggers CDK5 hyperactivation and translocation of the p25/CDK5 complex to the cytoplasm where it hyperphosphorylates a number of substrates, leading to neuronal death [13].
Positive_regulation (hyperactivation) of p25 in neuronal associated with death
18) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920814 Disease Relevance 0.90 Pain Relevance 0.20
Cerebral increase of CDK5/p25 activity was observed 3 hrs after the insult and prevented by systemic (S)-roscovitine administration.
Positive_regulation (increase) of p25
19) Confidence 0.09 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2920814 Disease Relevance 0.45 Pain Relevance 0.09
They found that resveratrol reduced significantly the extent of neuronal cell death and neurotoxicity of the mutant proteins expressed in these two models (p25, a toxic coactivator of CDK5, and a mutant form of superoxide dismutase 1, respectively).
Positive_regulation (coactivator) of p25 in neuronal associated with drug induced neurotoxicity and death
20) Confidence 0.08 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2546476 Disease Relevance 1.14 Pain Relevance 0.09

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