INT201764

Context Info Confidence 0.10 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.15 Pain Relevance 0.19

extracellular region (BDNF, Bdnf) cytoplasmic membrane-bounded vesicle (BDNF, Bdnf)

Anatomy Link Frequency hippocampus 2 BDNF (Homo sapiens) Bdnf (Mus musculus)

Pain Link Frequency Relevance Heat Hippocampus 7 100.00 long-term potentiation 5 99.84 Central nervous system 4 30.96 Inflammation 9 5.00 cytokine 8 5.00 Eae 6 5.00 Kinase C 5 5.00 Neurotransmitter 5 5.00 Neuropeptide 2 5.00 Inflammatory mediators 2 5.00

Disease Link Frequency Relevance Heat Disease 127 99.42 Amyloid Plaque 5 86.08 Cognitive Disorder 16 81.92 Targeted Disruption 3 79.92 Death 56 61.04 Apoptosis 133 50.00 Frailty 2 38.84 Injury 7 30.64 Aging 5 13.52 Neurodegenerative Disease 36 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Besides NGF, it must be acknowledged also the role of BDNF in AD, given the well established role of this neurotrophin in synaptic plasticity of the hippocampus and the requirement for BDNF in long-term potentiation (LTP) during learning and memory processes [87].

neurotrophin Regulation (role) of Positive_regulation (requirement) of BDNF in hippocampus associated with long-term potentiation, hippocampus and disease

1) Confidence 0.10 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 1.15 Pain Relevance 0.19

General Comments

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