INT202311

Context Info Confidence 0.02 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.70 Pain Relevance 0.16

extracellular space (Fn1) extracellular region (PDGFB) cell adhesion (Fn1) proteinaceous extracellular matrix (Fn1) extracellular matrix organization (Fn1) cytoplasm (PDGFB)

Anatomy Link Frequency extracellular matrix 2 PDGFB (Homo sapiens) Fn1 (Mus musculus)

Pain Link Frequency Relevance Heat fibrosis 17 92.00 Inflammatory response 1 73.04 Inflammation 6 44.80 dexamethasone 1 42.56 cytokine 9 5.00 antagonist 2 5.00 cINOD 1 5.00 tolerance 1 5.00

Disease Link Frequency Relevance Heat Fibrosis 19 96.68 Disease 4 85.56 Radiation Sickness 2 79.04 Pulmonary Fibrosis 8 78.12 INFLAMMATION 8 72.68 Bronchopulmonary Dysplasia 1 31.68 Pneumonia 3 7.52 Cancer 42 5.00 Glioma 9 5.00 Desmoid Disease 4 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

Moreover, PDGF was also shown to stimulate production of extracellular matrix proteins, such as collagen, hyaluronic acid, fibronectin and proteoglycan [80-83], which are mainly responsible for the irreversibility of fibrotic lesion.

PDGF Positive_regulation (stimulate) of Gene_expression (production) of fibronectin in extracellular matrix associated with fibrosis

1) Confidence 0.02 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 0.70 Pain Relevance 0.16

General Comments

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